Colorectal cancer screening Cancer Colorectal cancer
Conditions
Interventions
Sigmoidoscopy offered once in the life in the intervention group
usual care in the control group.
Sigmoidoscopy:
Bowel preparation was limited to a single enema (133 ml of 22% sodium phosphate) self-administered at home 2 hours befo
Sponsors
Italian Association for Cancer Research (Associazione Italiana per la Ricerca sul Cancro [AIRC]) (Italy)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Eligible, interested respondents to a mail questionnaire sent to a random population sample of men and women aged 55 to 64 years.
Exclusion criteria
Exclusion criteria: 1. Personal history of colorectal cancer, adenomas, inflammatory bowel disease, recent colorectal endoscopy 2. Subjects mentioning two first-degree relatives with colorectal cancer 3. Subjects unable to give informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To quantify the reduction in CRC incidence (measured at 10 years) and mortality (measured at 11 years). | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To determine the duration of efficacy of a single flexible sigmoidoscopy, measured up to 15 years from randomisation 2. To determine the optimum age for the examination, measured at 10 and 11 years 3. To assess acceptability and organisational impact (evaluated in the recruitment phase) | — |
Countries
Italy
Outcome results
None listed