Breast Cancer Breast
Conditions
Interventions
All patients receive either a total mastectomy or tumour excision followed by radiotherapy. Eligible patients are randomised to receive:
A. PRE-MENOPAUSAL PATIENTS
1.
Sponsors
Pharmacia Ltd & Upjohn (UK)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Aged <65 years 2. Tumour confined to the breast or breast and ipsilateral axilla and considered operable 3. At least one axillary lymph node must show evidence of tumour on histological examination 4. On clinical examination, the axillary nodes should be moveable in relation to the chest wall and neurovascular bundle, and there should be no oedema of the arm 5. Adequate renal, hepatic and haematological function 6. No previous oophorectomy for breast carcinoma 7. No evidence of metastatic disease 8. Patients with advanced disease or ulceration, erythema, infiltration of the skin and oedema are ineligible 9. No previous concomitant malignancy, except squamous or basal cell carcinoma of the skin or carcinoma in-situ of the cervix 10. No non-malignant systemic disease which would preclude the use of any treatment within the trial
Exclusion criteria
Exclusion criteria: Not provided at time of registration
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Secondary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Countries
United Kingdom
Outcome results
None listed