Restrictive versus standard fluid regime in patients undergoing elective infrarenal abdominal aortic aneurysm (AAA) repair

A prospective randomised clinical trial comparing a restrictive with a standard fluid regime in patients undergoing elective infrarenal abdominal aortic aneurysm (AAA) repair

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN27753612

Enrollment

Registered

2009-03-31

Start date

2007-01-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Abdominal aortic aneurysm Circulatory System Aortic aneurysm and dissection

Interventions

In the standard regimen patients will be given standard fluid volume intra-operatively and post-operatively until day 5, consisting of 3 litres per day. However in the restricted group, less fluid wil

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Adult patients (aged 18 years and over, either sex) admitted for elective open repair of AAA

Exclusion criteria

Exclusion criteria: 1. Patients with established renal failure 2. Pre-operative haematological disorder 3. Known allergy to agents specified in the standardised anaesthetic protocol 4. Lack of consent 5. Participation in other trials within 30 days

Design outcomes

Primary

Measure	Time frame
The difference in the number of patients with post-operative complications between the restrictive and standard treated groups.	—

Secondary

Measure	Time frame
1. Duration of hospital stay - recorded on discharge 2. Re-admission to Intensive Care Unit (ICU)/High Dependency Unit (HDU) and length of ICU/HDU stay - recorded following discharge from ICU 3. Oxygen saturation/fraction of inspired oxygen (FiO2):partial pressure of oxygen in arterial blood (PaO2) ratio - measured at baseline, and daily until day 5 4. Need for renal replacement therapy/estimated glomerular filtration rate (eGFR) - measured at baseline, and daily until day 5 5. First day of initial passage of flatus or faeces - recorded on occurrence 6. Differences in body weight - measured at baseline, and daily until day 5 7. Number of transfused platelet concentrates (PC)/fresh frozen plasma (FFP)/platelets - measured daily until day 5 8. Haematocrit - measured at baseline, and daily until day 5 9. Urinary albumin/creatinine ratio - measured at baseline, and daily until day 5 10. Sequential Organ Failure Assessment (SOFA) score - measured at baseline, and daily until day 5	—

Measure

Time frame

1. Duration of hospital stay - recorded on discharge 2. Re-admission to Intensive Care Unit (ICU)/High Dependency Unit (HDU) and length of ICU/HDU stay - recorded following discharge from ICU 3. Oxygen saturation/fraction of inspired oxygen (FiO2):partial pressure of oxygen in arterial blood (PaO2) ratio - measured at baseline, and daily until day 5 4. Need for renal replacement therapy/estimated glomerular filtration rate (eGFR) - measured at baseline, and daily until day 5 5. First day of initial passage of flatus or faeces - recorded on occurrence 6. Differences in body weight - measured at baseline, and daily until day 5 7. Number of transfused platelet concentrates (PC)/fresh frozen plasma (FFP)/platelets - measured daily until day 5 8. Haematocrit - measured at baseline, and daily until day 5 9. Urinary albumin/creatinine ratio - measured at baseline, and daily until day 5 10. Sequential Organ Failure Assessment (SOFA) score - measured at baseline, and daily until day 5

—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Apr 2, 2026