Cardiovascular disease and diabetes Circulatory System
Conditions
Interventions
Measurement of vascular function in the forearm by diffuse optical tomography during reactive hyperaemia response after brachial artery occlusion
Sponsors
Sheffield Teaching Hospitals NHS Foundation Trust
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Healthy volunteers 1. Aged between 18-80 years 2. Ability to read and speak English to a level allowing understanding of the patient information and to give consent to participate Diabetics: 1. Aged between 18-80 years 2. Ability to read and speak English to a level allowing understanding of the patient information and to give consent to participate 3. Diagnosed as type 1 or 2 diabetic for at least 12 months Prior myocardial infarction: 1. Aged between 18-80 years 2. Ability to read and speak English to a level allowing understanding of the patient information and to give consent to participate 3. Suffered a myocardial infarction at least 1 month previously Patients awaiting coronary angiography: 1. Aged between 18-80 years 2. Ability to read and speak English to a level allowing understanding of the patient information and to give consent to participate 3. Awaiting an invasive or CT coronary angiogram for clinical reasons
Exclusion criteria
Exclusion criteria: Healthy volunteers: 1. No history of diabetes, myocardial infarction, or major cardiovascular disease 2. No painful arms or health problems preventing blood pressure cuff inflation 3. No lymphoedema of the arm Diabetics: 1. No painful arms or health problems preventing blood pressure cuff inflation 2. No lymphoedema of the arm Prior myocardial infarction: 4. No painful arms or health problems preventing blood pressure cuff inflation 5. No lymphoedema of the arm Patients awaiting coronary angiography: 1. No painful arms or health problems preventing blood pressure cuff inflation 2. No lymphoedema of the arm 3. Not diabetic or known to have suffered a myocardial infarction in the past
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vascular function parameters measured by diffuse optical tomography after 5min brachial artery occlusion | — |
Secondary
| Measure | Time frame |
|---|---|
| Feasibility and reproducibility of vascular function measurement by diffuse optical tomography | — |
Countries
United Kingdom
Outcome results
None listed