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The use of patient’s own blood plasma derivative and palatal tissue graft in dental implant surgery

The use of platelet-rich fibrin in combination with sub-epithelial connective tissue graft in peri-implant soft tissue augmentation

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN27670172
Enrollment
110
Registered
2023-05-25
Start date
2021-10-01
Completion date
Unknown
Last updated
2023-06-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Improvement of gingival thickness in patients with thin gingiva biotype who undergoing dental implantation Oral Health

Interventions

Patients aged between 18 and 60 years with single or multiple non-restorable teeth were selected according to inclusion and exclusion criteria. The patients were randomly assigned to two groups using
Group I received delayed dental implantation with SCTG and PRF membrane during the second-stage implant surgery while Group II received delayed dental implantation with SCTG during the second-stage im

Sponsors

Kazakh National Medical University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Aged 18-60 years 2. Patients with single or multiple non-restorable teeth 3. Thin biotype of gingiva 4. Sufficient bone of alveolar ridge 5. Absence of untreated periodontal disease

Exclusion criteria

Exclusion criteria: 1. Pregnancy 2. Systemic diseases 3. Thick biotype 4. Insufficient bone

Design outcomes

Primary

MeasureTime frame
1. Width of the keratinized tissue determined by measuring the distance between the mucogingival junction (MGJ) and free gingiva using a graduated periodontal probe at baseline, 3 and 6 months after the surgical procedure 2. Thickness measured by the cone-beam computed tomography (CBCT) with Ez3D-1 software (Vatech, Korea) before and 3, 6 months after the surgical procedure. The measurement of the thickness of mucous for determination of biotype was provided according to the following steps: before the examination in the vestibule site of the oral cavity dental cotton swabs were put, measurements are carried out in the frontal and sagittal dimensions in areas corresponding to the vestibular cortical plates of the root of the examined tooth, in the projection of the central axis of the tooth, from the top of the cortical plate to the mucogingival junction.

Secondary

MeasureTime frame
1. Wound healing (epithelialization) measured using a cytological analysis at baseline, 3, 5, 7, and 10 days 2. Local immunity measured using a sandwich enzyme-linked immunosorbent assay (ELISA) for determination of the concentration of pro- and anti-inflammatory cytokines (IL-1ß, TNFa and IL-4) in the peri-implant cervicular fluid at baseline, 1, 7 and 30 days 3. Gingival blood flow measured using a laser Doppler flowmetry (LDF) at baseline,1, 7 and 14 days 4. Esthetic result (mesial and distal papilla, soft tissue level, soft tissue contour, alveolar process deficiencies, soft tissue color, and texture) measured using a Pink esthetic score (PES) at 6 months after the prosthetic phase

Countries

Kazakhstan

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 5, 2026