Evaluation of a mix of plant-derived extracellular vesicles for skin ageing in healthy women aged 45–65 years

Evaluation of a food supplement containing a mix of plant-derived extracellular vesicles compared with placebo on skin ageing parameters in healthy women aged 45–65 years: a randomized, placebo-controlled, double-blind clinical trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN27649559

Enrollment

Registered

2026-08-07

Start date

2026-07-20

Completion date

Unknown

Last updated

2026-08-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Age-related skin ageing in healthy women aged 45–65 years Skin and Connective Tissue Diseases

Interventions

Participants will be randomly assigned to either the ExoComplex® Longevity group or the placebo group in a parallel-group, double-blind study. Randomisation will be performed using a computer-generate

Eligibility

Sex/Gender

Female

Age

45 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Healthy female volunteers 2. Age between 45 and 65 years 3. Presence of visible signs of skin ageing, including dull and tired-looking skin 4. Ability and willingness to provide written informed consent and comply with all study procedures

Exclusion criteria

Exclusion criteria: 1. Pregnancy or breastfeeding 2. Known allergy or hypersensitivity to any component of the study product 3. Current dermatological disorders affecting the face 4. Use of systemic or topical treatments that may interfere with the study outcomes within the protocol-defined washout period 5. Participation in another clinical study within the previous 30 days 6. Any medical condition that, in the investigator's opinion, could interfere with study participation or interpretation of the results

Design outcomes

Primary

Measure	Time frame
Skin hydration measured using corneometry using the Corneometer® CM 825 (C+K electronic GmbH) at baseline, 1 month, 2 months and 3 months	—

Secondary

Measure	Time frame
Transepidermal water loss measured using the Tewameter® TM Hex (C+K electronic GmbH) at baseline, 1 month, 2 months and 3 months;Skin elasticity measured using the Cutometer® MPA 580 (C+K electronic GmbH) at baseline, 1 month, 2 months and 3 months;Skin collagen index measured using DermaScan Cortex Technology at baseline, 1 month, 2 months and 3 months;Skin brightness measured using the Skin-colorimeter® CL 400 (C+K electronic GmbH) at baseline, 1 month, 2 months and 3 months;Skin fatigue measured using clinical and instrumental evaluation according to the study protocol at baseline, 1 month, 2 months and 3 months	—

Measure

Time frame

Transepidermal water loss measured using the Tewameter® TM Hex (C+K electronic GmbH) at baseline, 1 month, 2 months and 3 months;Skin elasticity measured using the Cutometer® MPA 580 (C+K electronic GmbH) at baseline, 1 month, 2 months and 3 months;Skin collagen index measured using DermaScan Cortex Technology at baseline, 1 month, 2 months and 3 months;Skin brightness measured using the Skin-colorimeter® CL 400 (C+K electronic GmbH) at baseline, 1 month, 2 months and 3 months;Skin fatigue measured using clinical and instrumental evaluation according to the study protocol at baseline, 1 month, 2 months and 3 months

—

Countries

Italy

Contacts

Public ContactMariantonia Logozzi

mariantonia.logozzi@exolabitalia.com+39 (0)3285762894

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Aug 25, 2026