Anaemia Haematological Disorders Anaemia
Conditions
Interventions
Blood transfusion:
1. We are investigating anaemic haematology patients and determining their exercise capacity before and after transfusion by means of cardio-pulmonary exercise testi
Sponsors
Royal Victoria Infirmary Newcastle (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients requiring blood transfusion under the care of the haematology team 2. Patients over the age of 18 years 3. Capacity to give informed consent 4. Comprehension of English 5. Ability to undertake CPX testing using a cycle ergometer
Exclusion criteria
Exclusion criteria: 1. A requirement to have an urgent blood transfusion as judged by the haematologist caring for the patient. (This would not allow sufficient time to undertake proper consent and perform CPX tests one and two). 2. Ongoing active bleeding 3. Those who get angina or intermittent claudication on moderate exercise or who have shortness of breath at rest 4. Patients who have a significant acute medical illness 5. Those with other contraindications to exercise testing according to the ACC/AHA Exercise Testing Guidelines or our own local guidelines
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The change in anaerobic threshold following blood transfusion | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The change in AT per unit (g/dL) change in Hb concentration will be determined to correct for the variable change in Hb seen with blood transfusion 2. Changes in other CPX variables following transfusion, including peak VO2, OEUS (Oxygen Efficiency Utilisation Slope), Ve/VCO2 ratio, VO2/HR ratio and Respiratory Exchange Ratio (RER) 3. Intra-patient variability in the AT measured by CPX testing will be expressed as the coefficient of variation | — |
Countries
United Kingdom
Outcome results
None listed