COBRA : Cost and Outcome of BehaviouRal Activation

Conditions

Depression Mental and Behavioural Disorders Depressive episode, unspecified

Richards DA, Rhodes S, Ekers D, McMillan D, Taylor RS, Byford S, Barrett B, Finning K, Ganguli P, Warren F, Farrand P, Gilbody S, Kuyken W, O'Mahen H, Watkins E, Wright K, Reed N, Fletcher E, Hollon SD, Moore L, Backhouse A, Farrow C, Garry J, Kemp D, Plummer F, Warner F, Woodhouse R.

2017-08-0124 citations

10.3310/hta21460

Cost and outcome of behavioural activation versus cognitive behavioural therapy for depression (COBRA): a qualitative process evaluation

Katie Finning, David Richards, Lucy Moore, David Ekers, Dean McMillan et al. (13 authors)

BMJ Open2017-04-0126 citations

10.1136/bmjopen-2016-014161

Cost and Outcome of Behavioural Activation versus Cognitive Behavioural Therapy for Depression (COBRA): a randomised, controlled, non-inferiority trial.

Richards DA, Ekers D, McMillan D, Taylor RS, Byford S, Warren FC, Barrett B, Farrand PA, Gilbody S, Kuyken W, O'Mahen H, Watkins ER, Wright KA, Hollon SD, Reed N, Rhodes S, Fletcher E, Finning K.

2016-07-23335 citations

10.1016/s0140-6736(16)31140-0

Cost and outcome of behavioural activation versus cognitive behaviour therapy for depression (COBRA): study protocol for a randomised controlled trial.

Rhodes S, Richards DA, Ekers D, McMillan D, Byford S, Farrand PA, Gilbody S, Hollon SD, Kuyken W, Martell C, O'Mahen HA, O'Neill E, Reed N, Taylor RS, Watkins ER, Wright KA.

2014-01-2122 citations

10.1186/1745-6215-15-29

Interventions

Behavioural Activation (BA): participants will receive a maximum of 20 sessions over 16 weeks with the option of four additional booster sessions. Sessions will be face to face, of one-hour duration,

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Persons aged 18 and older and over (no upper age limit) with Major Depressive Disorder (DSM) assessed by standard clinical interview [Structured Clinical Interview for Depression (SCID)] 2. Researchers will be trained to administer the SCID using established training and inter-rater reliability procedures that are in use at the Mood Disorders Centre for all the trials

Exclusion criteria

Exclusion criteria: 1. Persons who are alcohol or drug dependent, acutely suicidal or cognitively impaired 2. Have a bipolar disorder or psychosis/psychotic symptoms, ascertained by baseline research interviews 3. People currently in receipt of psychological therapy

Design outcomes

Primary

Measure	Time frame
Self-reported depression severity as measured by the PHQ9 at 12 & 18 months adjusting for baseline outcome values and stratification variables (symptom severity, site, antidepressant use) and fitting therapist as a random effects variable	—

Secondary

Measure	Time frame
1. Secondary process evaluation to investigate the moderating, mediating and procedural factors in BA and CBT which influence outcome 2. Direct and indirect costs of treatment and disease burden 3. Health-state utility (EQ5D) 4. DSM depression status and depression free days (SCID) 5. Health Related Quality of Life (SF-36) 6. Six month interim analysis on PHQ9	—

Countries

England, United Kingdom

Outcome results

None listed