Clinical and radiographical outcomes after pulpotomies using mineral trioxide aggregate mixed with distilled water or 2.25% sodium hypochlorite gel

Clinical and radiographical outcomes after pulpotomies using mineral trioxide aggregate mixed with distilled water or 2.25% sodium hypochlorite gel: a randomized controlled clinical trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN27453183

Enrollment

Registered

2025-01-23

Start date

2024-01-13

Completion date

Unknown

Last updated

2026-05-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental caries Oral Health

Interventions

Two experienced pediatric dentists (ICC > 0.8) selected 20 participants from 31 who were referred to the Department of Pediatric Dentistry. The selected participants, who had 40 second primary molars

Eligibility

Sex/Gender

All

Age

5 Years to 10 Years

Inclusion criteria

Inclusion criteria: 1. Participants aged between 5 and 10 years 2. Participants who were cooperative 3. Participants indicated for a pulpotomy treatment on their second primary molars

Exclusion criteria

Exclusion criteria: 1. Participants with compromised conditions 2. Participants exhibiting signs and symptoms indicative of pulp necrosis 3. Participants with a history of spontaneous pain in their second primary molars 4. Participants with a history of nocturnal pain in their second primary molars

Design outcomes

Primary

Measure	Time frame
1. Spontaneous pain is measured using a visual analog scale (VAS) at baseline, 3 months, 6 months, and 12 months 2. Pain on percussion is measured using a percussion test at baseline, 3 months, 6 months, and 12 months 3. Tooth mobility is measured using the Miller Mobility Index at baseline, 3 months, 6 months, and 12 months 4. Abscesses are measured using clinical examination at baseline, 3 months, 6 months, and 12 months 5. Fistulas are measured using clinical examination at baseline, 3 months, 6 months, and 12 months 6. Exfoliation of the treated tooth is measured using clinical examination at baseline, 3 months, 6 months, and 12 months 7. Furcal radiolucency is measured using periapical radiographic evaluation at baseline, 3 months, 6 months, and 12 months 8. Internal root resorption is measured using periapical radiographic evaluation at baseline, 3 months, 6 months, and 12 months 9. External root resorption is measured using periapical radiographic evaluation at baseline, 3 months, 6 months, and 12 months 10. Widening of the periodontal ligament is measured using periapical radiographic evaluation at baseline, 3 months, 6 months, and 12 months 11. Canal obliteration is measured using periapical radiographic evaluation at baseline, 3 months, 6 months, and 12 months	—

Measure

Time frame

1. Spontaneous pain is measured using a visual analog scale (VAS) at baseline, 3 months, 6 months, and 12 months 2. Pain on percussion is measured using a percussion test at baseline, 3 months, 6 months, and 12 months 3. Tooth mobility is measured using the Miller Mobility Index at baseline, 3 months, 6 months, and 12 months 4. Abscesses are measured using clinical examination at baseline, 3 months, 6 months, and 12 months 5. Fistulas are measured using clinical examination at baseline, 3 months, 6 months, and 12 months 6. Exfoliation of the treated tooth is measured using clinical examination at baseline, 3 months, 6 months, and 12 months 7. Furcal radiolucency is measured using periapical radiographic evaluation at baseline, 3 months, 6 months, and 12 months 8. Internal root resorption is measured using periapical radiographic evaluation at baseline, 3 months, 6 months, and 12 months 9. External root resorption is measured using periapical radiographic evaluation at baseline, 3 months, 6 months, and 12 months 10. Widening of the periodontal ligament is measured using periapical radiographic evaluation at baseline, 3 months, 6 months, and 12 months 11. Canal obliteration is measured using periapical radiographic evaluation at baseline, 3 months, 6 months, and 12 months

—

Secondary

Measure	Time frame
There are no secondary outcome measures	—

Countries

Syria

Contacts

Public ContactMawia Karkoutly

Mawia95.karkoutly@damascusuniversity.edu.sy+963 992647528

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: May 16, 2026