Ascorbic Acid in open Abdominal Aortic Aneurysm repair

Non-invasive bed-side measurement of systemic endothelial function in patients undergoing abdominal aortic aneurysm repair: modulation by ascorbic acid

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN27369400

Enrollment

Registered

2008-11-12

Start date

2008-01-01

Completion date

Unknown

Last updated

2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Abdominal aortic aneurysm Circulatory System Aortic aneurysm

Interventions

Participants will be randomised to either 2 g intravenous ascorbic acid or placebo (0.9% saline) infusion for intra-operative administration. Total duration of treatment is time taken to administer th

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Adult patients (aged 18 years or over, either sex) admitted for elective open repair of abdominal aortic aneurysm in the Royal Victoria Hospital.

Exclusion criteria

Exclusion criteria: 1. Known history hyperoxaluria or glucose-6-phosphate dehydrogenase deficiency 2. Prior antioxidant therapy 3. Known allergy to ascorbic acid or agents specified in the standardised anaesthetic protocol 4. Lack of consent

Design outcomes

Primary

Measure	Time frame
Reduction in endothelial dysfunction as measured by plasma von Willebrand Factor (vWF) at fours hours post-removal of aortic cross clamp.	—

Secondary

Measure	Time frame
1. Systemic endothelial function as assessed by: 1.1. Adhesion molecules - soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble E-Selectin (sE-Selectin), measured pre-operatively and four hours post-removal aortic crossclamp 1.2. Urinary albumin:creatinine ratio (ACR), measured pre-operatively and four hours post-removal aortic crossclamp 1.3. Non-invasive assessment of endothelial function as determined by Pulse Wave Analysis, measured pre-operatively and four hours post-removal aortic crossclamp 2. Pulmonary endothelial dysfunction as measured by pulmonary dead space fraction, measured at post-intubation and pre-extubation approximately 1 hour post-cross clamp removal 3. Inflammatory response as measured by: 3.1. Highly sensitive C reactive protein (hsCRP), measured pre-operatively and four hours post-removal aortic crossclamp 3.2. Exhaled breath condensate pH, myeloperoxidase, and leukotriene B4, measured at post-intubation and pre-extubation approximately 1 hour post-cross clamp removal 4. Oxidative stress as measured by: 4.1. Serum lipid peroxides, measured pre-operatively and four hours post-removal aortic crossclamp 4.2. Urinary F2 isoprostanes, measured pre-operatively and four hours post-removal aortic crossclamp 4.3. Exhaled breath condensate hydrogen peroxide and 8-isoprostane, measured pre-operatively and four hours post-removal aortic crossclamp	—

Measure

Time frame

1. Systemic endothelial function as assessed by: 1.1. Adhesion molecules - soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble E-Selectin (sE-Selectin), measured pre-operatively and four hours post-removal aortic crossclamp 1.2. Urinary albumin:creatinine ratio (ACR), measured pre-operatively and four hours post-removal aortic crossclamp 1.3. Non-invasive assessment of endothelial function as determined by Pulse Wave Analysis, measured pre-operatively and four hours post-removal aortic crossclamp 2. Pulmonary endothelial dysfunction as measured by pulmonary dead space fraction, measured at post-intubation and pre-extubation approximately 1 hour post-cross clamp removal 3. Inflammatory response as measured by: 3.1. Highly sensitive C reactive protein (hsCRP), measured pre-operatively and four hours post-removal aortic crossclamp 3.2. Exhaled breath condensate pH, myeloperoxidase, and leukotriene B4, measured at post-intubation and pre-extubation approximately 1 hour post-cross clamp removal 4. Oxidative stress as measured by: 4.1. Serum lipid peroxides, measured pre-operatively and four hours post-removal aortic crossclamp 4.2. Urinary F2 isoprostanes, measured pre-operatively and four hours post-removal aortic crossclamp 4.3. Exhaled breath condensate hydrogen peroxide and 8-isoprostane, measured pre-operatively and four hours post-removal aortic crossclamp

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Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 17, 2026