Study of monitoring blood concentration of local anaesthetic after a nerve block in elderly patients with hip fracture

Pilot study of a plasma local anaesthetic monitoring regime after fascia iliaca block in elderly patients

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN27364035

Enrollment

Registered

2016-12-21

Start date

2016-11-14

Completion date

Unknown

Last updated

2019-10-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Specialty: Anaesthesia, perioperative medicine and pain management, Primary sub-specialty: Anaesthesia, Perioperative Medicine and Pain Management

Interventions

All patients recruited into the study are admitted to hospital with a fractured neck of femur and will receive an analgesic nerve block, called a fascia iliaca compartment block (FICB) prior to surger

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Informed consent: signed written informed consent before inclusion in the study 2. Radiologically-confirmed fractured neck of femur 3. Age 80 years and over 4. Scheduled to receive fascia iliaca compartment block (to be done by anaesthetic team, as per standard local care protocol)

Exclusion criteria

Exclusion criteria: 1. Patient refusal or incapacity 2. Patient on anticoagulation medication 3. INR > 3.0 4. Platelets 300 or receiving renal replacement therapy or dialysis 8. Patients requiring Level 2 or 3 care 9. Estimated weight 120kg

Design outcomes

Primary

Measure	Time frame
Pharmacokinetic profile of levobupivacaine is measured through blood testing on samples taken at baseline and 10, 20, 30, 45, 60, 75, 90, 105, 120, 240 minutes after the FICB.	—

Secondary

Measure	Time frame
1. Relationship between time and pain after fascia iliaca compartment block is measured through blood testing and visual analogue scale (VAS) on samples taken at baseline and 10, 20, 30, 45, 60, 75, 90, 105, 120, 240 minutes after the FICB 2. Range of alpha-1 glycoprotein plasma concentration in elderly patients with hip fracture is measured through blood testing on samples taken at baseline and 10, 20, 30, 45, 60, 75, 90, 105, 120, 240 minutes after the FICB 3. Patient demographics, renal function, intravenous fluid administration, supplemental analgesia requirements are measured using medical record review at baseline	—

Measure

Time frame

1. Relationship between time and pain after fascia iliaca compartment block is measured through blood testing and visual analogue scale (VAS) on samples taken at baseline and 10, 20, 30, 45, 60, 75, 90, 105, 120, 240 minutes after the FICB 2. Range of alpha-1 glycoprotein plasma concentration in elderly patients with hip fracture is measured through blood testing on samples taken at baseline and 10, 20, 30, 45, 60, 75, 90, 105, 120, 240 minutes after the FICB 3. Patient demographics, renal function, intravenous fluid administration, supplemental analgesia requirements are measured using medical record review at baseline

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Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 3, 2026