Delirium Signs and Symptoms Delirium, not induced by alcohol and other psychoactive substances
Conditions
Interventions
Rivastigmine up to 1.5 mg twice a day or placebo.
Sponsors
South Manchester University Hospitals NHS Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients over 65 years old 2. Admitted to elderly acute medical ward or orthopaedic ward 3. Patient has a delirium as measured on the Confusion Assessment Method or doesn't have a delirium and has a fractured neck of femur caused by trauma
Exclusion criteria
Exclusion criteria: 1. Patient already on cholinesterase inhibitor 2. Patient has had a previous adverse reaction to a cholinesterase inhibitor 3. If considered by medical team in charge of care to be in the terminal phase of illness 4. Acute chronic obstructive pulmonary disease (COPD) or asthma 5. Has a dysrhythmia on electrocardiogram (ECG) 6. Urea >20 or creatinine >200
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. If develops delirium as found on Confusion Assessment Method 2. Length of delirium, measured in days | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Length of admission 2. Change in mini-mental state examination score 3. Use of other psychotropic medication during treatment e.g. benzodiazepines | — |
Countries
United Kingdom
Outcome results
None listed