Safety and efficacy of the combination of chloroquine and methylene blue in the treatment of uncomplicated falciparum malaria in young children of Burkina Faso

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN27290841

Enrollment

225

Registered

2004-02-06

Start date

2004-01-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Uncomplicated falciparum malaria Infections and Infestations Malaria

Interventions

Arm A (N = 45): 25 mg/kg oral chloroquine within 3 days Arm B (N = 180): 25 mg/kg oral chloroquine and 15 mg/kg methylene blue within 3 days

Eligibility

Inclusion criteria

Inclusion criteria: 1. Children (6 - 59 months) with uncomplicated falciparum malaria 2. Greater than or equal to 2000 Plasmodium falciparum 3. Burkinabe nationality

Exclusion criteria

Exclusion criteria: 1. Complicated or severe malaria (repeated vomiting, seizures or other neurological impairment) 2. Anaemia (haemoglobin less than 8 g/dl or haematocrit less than 24%) 3. Any other apparent significant disease (e.g. pneumonia, meningitis, hepatitis, severe diarrhoea, measles, severe malnutrition)

Design outcomes

Primary

Measure	Time frame
Incidence of severe haemolysis or other serious adverse events (SAEs).	—

Secondary

Measure	Time frame
Efficacy outcomes were defined according to the WHO 2003 classification system.	—

Countries

Burkina Faso

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Apr 7, 2026