Volume expansion during major abdominal surgery Surgery Other complications of surgical and medical care, not elsewhere classified
Conditions
Interventions
Patients will be managed perioperatively according to the enhanced recovery protocol, which is well established and constitutes routine practice for all patients undergoing major abdominal surgery at
Sponsors
Guy's and St Thomas' NHS Foundation Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Both males and females 2. 18 years or over 3. Patients undergoing major abdominal surgery in the Enhanced Recovery After Surgery programme at Guy's and St Thomas' NHS Foundation Trust, UK 4. American Society of Anaesthesiologists (ASA) grade 1-3
Exclusion criteria
Exclusion criteria: 1. Known hypersensitivity to Gelofusine® or Geloplasma® 2. Oliguric or anuric renal dysfunction requiring dialysis 3. Estimated glomerular filtration rate (EGFR) New York Hearth Association [NYHA] class 2) 6. Liver insufficiency (aspartate aminotransferase >40 U/L, alanine aminotransferase >40 U/L) 7. Absence of written, informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The following will be monitored during the surgery and two hours in recovery: 1. Postoperative chloride level 2. Postoperative base excess | — |
Secondary
| Measure | Time frame |
|---|---|
| The following will be recorded for the duration of surgery, and two hours in recovery: 1. Postoperative pH 2. Volume of colloid given 3. Postoperative renal function 4. Postoperative nausea and vomiting 5. Urinary Sodium 6. Urine output | — |
Countries
United Kingdom
Outcome results
None listed