A randomised controlled trial of vitamins C and E to prevent pre-eclampsia in type one diabetic pregnancy

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN27214045

Enrollment

756

Registered

2004-03-31

Start date

2003-06-01

Completion date

Unknown

Last updated

2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pre-eclampsia Pregnancy and Childbirth Pre-eclampsia

Interventions

Vitamin C 1000 mg and vitamin E 400 IU or placebo daily from recruitment (eight to 22 weeks gestation) until delivery.

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Women with type one diabetes preceding pregnancy presenting before 22 weeks gestation

Exclusion criteria

Exclusion criteria: 1. Warfarin treatment 2. Multiple pregnancy 3. Gestational diabetes 4. Current or previous (within the last six weeks) ingestion of preparations containing vitamin C (more than 500 mg/day) or vitamin E (200 IU/day)

Design outcomes

Primary

Measure	Time frame
Incidence of pre-eclampsia, measured after delivery	—

Secondary

Measure	Time frame
1. Endothelial activation, measured at baseline, 26 weeks gestation and 34 weeks gestation 2. Birthweight centile, measured after delivery	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 31, 2026