Developing aspirin tolerance in patients who are allergic/sensitized to aspirin

Aspirin desensitization following endoscopic sinus surgery is effective in patients with NERD: A 1 year prospective and controlled study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN27096541

Enrollment

Registered

2022-01-25

Start date

2008-08-04

Completion date

Unknown

Last updated

2022-02-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aspirin treatment in patients with NERD (non-steroid-exacerbated respiratory disease) Respiratory

Interventions

The patients are non-randomly divided into 2 arms: 1. Active aspirin treatment arm: The patients in this group are desensitized to aspirin in our clinic for 1 week and tolerate a 600 m

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged 18 - 65 years 2. Aspirin hypersensitivity

Exclusion criteria

Exclusion criteria: 1. Pregnancy 2. Patients who are failed to be desensitized with aspirin (ie. anaphylaxis) 3. Patients who have a previous history of gastric bleeding

Design outcomes

Primary

Measure	Time frame
1. Asthma outcomes measured using patient records at 1st, 6th, and 12th months: 1.1 Severe asthma attacks which require at least 3 days of oral corticosteroid treatment 1.2 Hospitalizations due to asthma 1.3 Admission to emergency care and systemic corticosteroid use due to asthma in the last year 1.4. Medication use 1.5 Asthma control measured using the asthma control test 2. Sinonasal outcomes measured using patient records at 1st, 6th, and 12th months: 2.1 Nasal symptom (sneezing, nasal blockage, nasal itching) scores 2.2 Medication use 2.3 Number of sinusitis episodes in the last year 2.4 Number of nasal surgeries due to nasal polyposis in the last year 2.5 Nasal endoscopic findings measured using ENT	—

Measure

Time frame

1. Asthma outcomes measured using patient records at 1st, 6th, and 12th months: 1.1 Severe asthma attacks which require at least 3 days of oral corticosteroid treatment 1.2 Hospitalizations due to asthma 1.3 Admission to emergency care and systemic corticosteroid use due to asthma in the last year 1.4. Medication use 1.5 Asthma control measured using the asthma control test 2. Sinonasal outcomes measured using patient records at 1st, 6th, and 12th months: 2.1 Nasal symptom (sneezing, nasal blockage, nasal itching) scores 2.2 Medication use 2.3 Number of sinusitis episodes in the last year 2.4 Number of nasal surgeries due to nasal polyposis in the last year 2.5 Nasal endoscopic findings measured using ENT

—

Secondary

Measure	Time frame
Measured at 1st, 6th, and 12th months: 1. Asthma and rhinitis quality of life questionnaires 2. Pulmonary function tests 3. Eosinophil counts measured using blood test 4. Results of smell tests in the last year measured using olfaction test	—

Countries

Turkey

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026