Topic: Cardiovascular
Conditions
Interventions
Patients will first be screened and, if they are eligible, they will be randomly allocated to receive either unwashed (standard practice in UK) or washed RBC units, if they require a blood transfusion
Sponsors
University of Leicester (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Adult cardiac surgery patients (16 years to 80 years) undergoing cardiac surgery with blood cardioplegia 2. Identified as representing a high risk group for massive blood transfusion using a modified transfusion risk score Target Gender: Male & Female; Upper Age Limit 80 years ; Lower Age Limit 16 years
Exclusion criteria
Exclusion criteria: 1. Emergency or salvage procedure 2. Ejection fraction 10 mg/day of prednisolone). 6. Patients with congenital or acquired RBC, platelet or clotting factor disorders, (excluding those receiving anti-platelet therapy, warfarin or other systemic oral anticoagulants) 7. Patient in a critical preoperative state (Kidney Disease: Improving Global Outcomes (KDIGO) Stage 3 AKI or requiring ionotropes, ventilation or intra-aortic balloon pump) preoperatively 8. Pregnancy 9. Patients who are participating in another interventional clinical study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of the systemic inflammatory response as determined by serial cytokine measures; Timepoint(s): Over the first 96 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Countries
United Kingdom
Outcome results
None listed