Non-axial chronic osteomyelitis due to Staphylococcus aureus Musculoskeletal Diseases Chronic osteomyelitis
Conditions
Interventions
After surgery and identification of Staphylococcus aureus upon surgical samples, randomisation of patients for antibiotic therapy:
Group A: intravenous cloxacillin (2 g every four hours [q4h]) for 6
Sponsors
Institute of Biomedical Investigations of Bellvitge (Institut d'Investigació Biomèdica de Bellvitge) (IDIBELL) (Spain)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Adult patients (greater than 18 years old) of any gender with chronic osteomyelitis by Staphylococcus aureus treated with surgery.
Exclusion criteria
Exclusion criteria: 1. Prosthetic joint infection 2. Methicillin resistant Staphylococcus aureus 3. Allergy to protocol antibiotics 4. Strain resistance to cotrimoxazole or rifampin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Treatment failure rate, defined as the number of cases with clinical relapse (appearance or recurrence of local inflammatory signs or sinus tract drainage, with or without microbiological confirmation) during follow-up. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Treatment tolerability and compliance (number of patients who did not fulfil protocol treatment and reason), from patient inclusion to the end of antibiotic therapy (8 weeks) 2. Length of hospital stay (days) for each treatment schedule; defined as hospitalisation during the diagnosis and treatment of the episode | — |
Countries
Spain
Outcome results
None listed