Poor ovarian response in In Vitro Fertilisation (IVF) Pregnancy and Childbirth Poor ovarian response in In Vitro Fertilisation (IVF)
Conditions
Interventions
Each intervention group will be receiving one of the following treatments:
1. The Gonadotrophin Releasing Hormone (GnRH) agonist long regimen
2. The GnRH agonist short regimen
3. The GnRH antagonist r
Sponsors
Guy's and St Thomas' NHS Foundation Trust and King' s College London (UK)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Any woman undergoing an IVF treatment cycle with or without Intra Cytoplasmic Sperm Injection (ICSI) who is considered to be a "poor responder" is eligible to participate in the trial. For this study a "poor responder" is defined as a woman who had a previous IVF treatment cycle in which she was stimulated with a daily dose of Follicle Stimulating Hormone (FSH) of 300 IU or more for at least nine days and: 1. Produced an inadequate number of mature follicles (three or less follicles measuring more than or equal to 17 mm, or 2. Had three or less oocytes retrieved at oocyte retrieval
Exclusion criteria
Exclusion criteria: 1. Women aged more than 40 years 2. Women with a single ovary
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of oocytes retrieved at egg collection | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Total FSH dose used for ovarian stimulation 2. Number of mature oocytes retrieved 3. Number of embryos available for transfer 4. Clinical pregnancies (ultrasound evidence of foetal heart at eight weeks gestation) | — |
Countries
United Kingdom
Outcome results
None listed