Untreated borderline hypercholesterolaemia Nutritional, Metabolic, Endocrine
Conditions
Interventions
74 men and women with elevated blood cholesterol will be recruited. There will be an initial visit during which volunteers will be screened for blood cholesterol to make sure they are suitable to take
Sponsors
The University of Aberdeen
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 30-65 years 2. Borderline/untreated high cholesterol levels
Exclusion criteria
Exclusion criteria: 1. Systolic BP above 159 mmHg or below 90 mmHg, and/or with diastolic blood pressure above 89 mmHg or below 60 mmHg 2. Cardiovascular disease (CVD), diabetes or fasting blood glucose concentration >7.0 mmol/l, asthma or thyroid conditions 3. Eating disorders, high habitual intake of wholegrain food (>21 portions per week) or taking regular medication or supplements known to affect any dependant variable measured
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Plasma total cholesterol 2. Plasma HDL-cholesterol 3. ApoA1 4. ApoB100 5. Triacyclglycerol (TAG, triglycerides) 6. Glucose All blood tests will be performed using standard laboratory analysis using blood samples taken at weeks 2, 8, 10, 16 and 20. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Participant-reported compliance to the intervention assessed by examining food diaries 2. Alkylresorcinol levels assessed by HPLC analysis of plaasma and urine samples taken at weeks 2, 8, 10, 16 and 20. 3. Markers of inflammation (GlycA, hsCRP, IL6, serum amyloid A, oxidised LDL) will be measured by immunoassays using blood samples taken at weeks 2, 8, 10, 16 and 20 3. Gut microbiota activity assessed using markers such as plasma trimethylamine oxide measured by by liquid chromatography/mass spectrometry using blood samples taken at weeks 2, 8, 10, 16 and 20 | — |
Countries
United Kingdom
Outcome results
None listed