Rapid intervention with glyceryl trinitrate in hypertensive stroke trial-2

Conditions

Topic: Stroke

Lisa J Woodhouse, Jason P. Appleton, Sandeep Ankolekar, Timothy J. England, Grant Mair et al. (17 authors)

BMJ Neurology Open2023-06-011 citations

10.1136/bmjno-2023-000424

Time intervals and distances travelled for prehospital ambulance stroke care: data from the randomised-controlled ambulance-based Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2)

Mark Dixon, Jason P. Appleton, Polly Scutt, Lisa J Woodhouse, Lee J Haywood et al. (9 authors)

BMJ Open2022-11-016 citations

10.1136/bmjopen-2021-060211

Imaging markers of small vessel disease and brain frailty, and outcomes in acute stroke

Jason P. Appleton, Lisa J Woodhouse, Alessandro Adami, Jennifer Becker, Eivind Berge et al. (17 authors)

Neurology2019-12-28140 citations

10.1212/wnl.0000000000008881

Prehospital Transdermal Glyceryl Trinitrate for Ultra-Acute Intracerebral Hemorrhage

Philip M. Bath, Lisa J Woodhouse, Kailash Krishnan, Jason P. Appleton, Craig S. Anderson et al. (28 authors)

Stroke2019-10-0769 citations

10.1161/strokeaha.119.026389

Multicentre Randomised trial of Acute Stroke treatment in the Ambulance with a nitroglycerin Patch (MR ASAP): study protocol for a randomised controlled trial.

van den Berg SA, Dippel DWJ, Hofmeijer J, Fransen PSS, Caminada K, Siegers A, Kruyt ND, Kerkhoff H, de Leeuw FE, Nederkoorn PJ, van der Worp HB, MR ASAP Investigators.

2019-06-2618 citations

10.1186/s13063-019-3419-z

Prehospital transdermal glyceryl trinitrate in patients with ultra-acute presumed stroke (RIGHT-2): an ambulance-based, randomised, sham-controlled, blinded, phase 3 trial.

RIGHT-2 Investigators.

2019-02-06142 citations

10.1016/s0140-6736(19)30194-1

Baseline characteristics of the 1149 patients recruited into the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2) randomized controlled trial

Philip M. Bath, Polly Scutt, Jason P. Appleton, Mark Dixon, Lisa J Woodhouse et al. (7 authors)

International Journal of Stroke2018-11-269 citations

10.1177/1747493018816451

Statistical analysis plan for the ‘Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2)’

Polly Scutt, Jason P. Appleton, Mark Dixon, Lisa J Woodhouse, Nikola Sprigg et al. (10 authors)

European Stroke Journal2018-02-0110 citations

10.1177/2396987318756696

Ambulance-delivered transdermal glyceryl trinitrate versus sham for ultra-acute stroke: Rationale, design and protocol for the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2) trial (ISRCTN26986053)

Jason P. Appleton, Polly Scutt, Mark Dixon, Harriet Howard, Lee J Haywood et al. (15 authors)

International Journal of Stroke2017-08-0124 citations

10.1177/1747493017724627

Interventions

Transdermal Glyceryl Trinitrate patch 5mg, daily for 4 days or sham patch for 4 days.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients presenting to paramedics in context of 999 ambulance call for ‘stroke’ 2. Age 18 years or more (there is no maximum age) 3. ‘Face/Arm/Speech’ Time (FAST) score >1 4. Time =120 mmHg 6. Have provided informed consent, or a relative/paramedic has provided proxy consent 7. Paramedic is trained in RIGHT2 procedures, is from a participating ambulance station and will take patient to a participating comprehensive/primary stroke centre

Exclusion criteria

Exclusion criteria: 1. Patient at a Nursing or Care Home 2. Glucose (BM stix) <2.5 mmol/l 3. Glasgow Coma Scale <8 4. Witnessed seizure/fit at presentation 5. Known life expectancy <6 months 6. Known to have taken a PDE5 inhibitor, such as sildenafil, in previous day before stroke 7. Known sensitivity to Transiderm Nitro patch 8. Known sensitivity to Duoderm hydrocolloid dressing

Design outcomes

Primary

Measure	Time frame
Death/dependence/independence: 7-level modified Rankin Scale 90 days after stroke	—

Countries

England, United Kingdom

Contacts

Public ContactDiane Havard

Outcome results

None listed