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Can people with substance misuse and depression benefit from brief psychological therapies?

COmorbidity and Brief Interventions for Depression: The COBID Study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN26937594
Enrollment
60
Registered
2012-02-27
Start date
2012-03-19
Completion date
Unknown
Last updated
2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mild to moderate substance misuse and depression Mental and Behavioural Disorders Depressive episode, unspecified

Interventions

Comparing behavioural activation with a minimal treatment intervention (1 session self-help and bibliotherapy) Behavioural Activation (BA) is a structured psychological intervention for depression ba
Hopko et al., 2003). Essentially, it consists of: 1. Self-monitoring to identify depressive and maladaptive behaviours 2. Scheduling activities aiming to reinforce adaptive behaviour patterns 3. Redu
in addition the research team will organise a full-day training event to orientate therapists to this

Sponsors

NHS Leeds (UK)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Are currently engaging with a community drugs treatment, detox, maintenance or addiction recovery focused service in Leeds. Engagement is defined by: 1.1. Being currently registered with a formal addiction focused service or programme 1.2. Having had planned contact with the service within the last month 2. Meet criteria for a current depressive disorder as defined by a score of 12 or more on the PHQ-9 questionniare. Comorbid anxiety disorders are not exclusion criteria, as long as depression is the primary disorder 3. Meet criteria for mild-to-moderate severity of drug dependence, as defined by a score between 0 ? 10 on the Severity of Dependence Questionnaire 4. Have used alcohol, drugs, or methadone maintenance medication within the last month

Exclusion criteria

Exclusion criteria: 1. Are not currently engaging in a formal addiction treatment or support programme in Leeds 2. Do not currently meet criteria as clinically significant for depressive disorder as defined by the PHQ-9 questionnaire score 3. Meet criteria for depression and a comorbid anxiety disorder, as identified by the GAD-7 questionnaire. Where the anxiety disorder is more severe, has been of longer duration than depressive symptoms and is the patient's main concern. 4. Meet criteria for a severe mental disorder including bipolar affective disorder, schizophrenia or other psychotic disorders. Patients with severe mental health problems who are already involved in psychiatric or secondary care mental health services. 5. Are free of substances of dependence and/or maintained on disulfiram, acamprosate or naloxone. 6. Those who have a severe drug or alcohol dependence, as defined by a score above 10 on the Severity of Dependence Questionnaire.

Design outcomes

Primary

MeasureTime frame
Patient Health Questionnaire (PHQ-9) Measured at baseline, then 6 weeks post therapy and 12 weeks post therapy.

Secondary

MeasureTime frame
1. Generalised Anxiety Disorder (GAD-7) 2. Treatment Outcomes Profile (TOP) 3. Substance misuse section of PRISM Measured at baseline, then 6 weeks post therapy and 12 weeks post therapy.

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026