Topic: Metabolic and Endocrine, Oral and Gastrointestinal
Conditions
Interventions
Participants will be assigned to the exercise or control group. The exercise group will undergo 8 weeks of resistance training 3 times per week. The intensity of the programme will be tailored to each
Sponsors
Newcastle upon Tyne Hospitals NHS Foundation Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Diagnosed NAFLD or raised liver enzymes 2. Type 2 diabetes (diet or metformin controlled) 3. Body mass index (BMI) between 25 - 35 kg/m^2 4. Aged 18 - 70 years 5. Subjects should not already take part in regular exercise
Exclusion criteria
Exclusion criteria: 1. Subjects with kidney disease or in vivo ferrous metal 2. Subjects that have other pre-existing medical conditions which could prevent them from exercising 3 x per week 3. Subjects with type 2 diabetes on insulin or insulin sensitising treatments 4. Subjects with advanced liver disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| A quantitative measure of liver fat will be made using H magnetic resonance spectroscopy. Primary and secondary outcome measures will be made at baseline and after the 8 week exercise intervention/8 week control period. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Insulin sensitivity 2. Lipid oxidation 3. Cytokine production 4. Regional adiposity 5. Body composition Primary and secondary outcome measures will be made at baseline and after the 8 week exercise intervention/8 week control period. | — |
Countries
United Kingdom
Outcome results
None listed