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How effective are antibiotics in preventing postoperative complications in patients after tooth extraction surgery?

Efficacy of antibiotics treatment in preventing postoperative complications in patients after tooth extraction surgery: a prospective, randomized, double-blind controlled study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN26679089
Enrollment
200
Registered
2018-12-18
Start date
2015-07-01
Completion date
Unknown
Last updated
2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pericoronitis Oral Health

Interventions

Patients in the treatment group took amoxicillin 0.5g/ and metronidazole 0.2g one hour postoperatively (three times every day) for three days after tooth extraction. Patients in the placebo group took
Random Allocation Software, Isfahan, Iran)

Sponsors

Hospital of Nanjing University of Science and Technology
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Current inclusion criteria: 1. Have pericoronitis in the distal aspect of a third molar and pericoronitis-related lymphadenopathy. 2. Have indication for extraction of the third molars due to recurrent infections (at least two times) occurred at certain intervals. 3. Had tooth in the vertical position. 4. Had operculum covering 1/2–2/3 of the outer surface of the tooth. Previous inclusion criteria: 1. Have pericoronitis in the distal aspect of the mandibular third molars and pericoronitis-related lymphadenopathy. 2. Have indication for extraction of the third molars due to recurrent infections (at least two times) occurred at certain intervals. 3. Had tooth in the vertical position. 4. Had operculum covering 1/2–2/3 of the outer surface of the tooth.

Exclusion criteria

Exclusion criteria: 1. Have a systemic disease 2. Pregnant women or women having suspicion of pregnancy 3. Lactating women 4. Received bisphosphonate at any time 5. Received antibiotic or anti-inflammatory drugs within the last month

Design outcomes

Primary

MeasureTime frame
1. Pain was measured using a visual analogue score (VAS) at 7th days after tooth extraction. 2. Swelling was measured as the difference between the distance (mm) between the lower earlobe and the mesomentum on the extraction side at 7th days after tooth extraction. 3. Mouth opening degree was measured as the distance between upper and lower incisors at 7th days after tooth extraction.

Secondary

MeasureTime frame
Alveolitis event was diagnosed by a dry appearance of the exposed bone in the socket after trauma.

Countries

China

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026