Patients with post-surgical cavities (no more than 1.5 cm after cystectomy, benign bone tumor removal, impacted tooth extraction) Surgery
Conditions
Interventions
The study was conducted among 200 patients aged 18 to 60 years who underwent surgery to remove cysts, benign bone formations of the jaw bones and extraction of impacted teeth (after the operation, bon
comparison group B (30 patients) where xenogenic bone material (BioOss, Switzerland) was imlanted
comparison group C (25 patients) in which ß-tricalcium phosphate (Sorbone, South Korea) was used. 40 patients formed a control group in which after surgery the bone defect was filled with a blood clot
Sponsors
Kazakh National Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients aged 18 to 60 years 2. Patients who underwent surgery to remove cysts, benign bone formations of the jaw bones and extraction of impacted teeth 3. After the operation, bone defects were formed to be filled with a diameter of no more than 1.5 cm
Exclusion criteria
Exclusion criteria: 1. Pregnancy 2. Systemic diseases 3. After the operation, bone defects were formed to be filled with a diameter of more than 1.5 cm
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Reparative osteogenesis measured using bone trephine during dental implantation at 6 months after filling the bone cavities with PRPP or osteoplastic material 2. Bone healing measured using cone beam computed tomography (CBCT) with determination of bone density in the area of the filled bone defect and performed in Hounsfield units (HU) at 1, 3, 6, and 12 months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Local immunity and anti-inflammation effect of PRPP, measured by evaluation of pro- and anti-inflammatory cytokines (IL-1ß, TNFa and IL-4) in the wound fluid with sandwich enzyme-linked immunosorbent assay on the 1st, 7th and 30th days after the operation 2. Wound healing (mucous healing) is measured using cytological analyses on days 1, 3, 5, 7, and 10 after the surgical procedure | — |
Countries
Kazakhstan
Outcome results
None listed