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Antiplaque and antigingivitis effect of lippia sidoides

Antiplaque and antigingivitis effect of lippia sidoides: A double-blind clinical study in humans

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN26530238
Enrollment
26
Registered
2008-09-12
Start date
2005-08-01
Completion date
Unknown
Last updated
2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gingivitis Oral Health Gingivitis and periodontal diseases

Interventions

Preparation of experimental gel: The essential oil of LS was extracted by steam distillation. Initially, 1 ml of essential oil was diluted in 9 ml of ethylic alcohol (1:9), preparing a 10% mixture. 50

Sponsors

University of Fortaleza (Brazil)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: All subjects (both males and females, aged 19 to 25 years) had at least 20 natural teeth, 4 of which were posterior teeth in the lower left quadrant (experimental teeth)

Exclusion criteria

Exclusion criteria: 1. Medical disorders 2. Under antimicrobial therapy 3. Smokers 4. Pregnant women 5. Individuals presenting a probing depth >3 mm associated with any mandibular teeth 6. Subjects with retentive factors of dental plaque, such as carious cavity and excess restoration in the test area

Design outcomes

Primary

MeasureTime frame
The indexes (plaque index, gingival index and bleeding index) were recorded on the mesiobuccal, buccal, distobuccal, mesiolingual, lingual and distolingual surfaces of the experimental teeth and their mean scores were calculated. Then, mean scores for the 4 experimental teeth in each participant were calculated to determine the mean index score for the individual. Intra-examiner agreement for all indexes was calculated by repeating the measurements in 10 participants. Timepoints of assessment: Baseline and at the end of each of the two 21-day experimental phases.

Secondary

MeasureTime frame
Adverse effects, such as abscess, ulcerations and allergic reactions. The patients will be submitted to weekly evaluations for the observation of side effects within a maximum period of 21 days.

Countries

Brazil

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026