Effects of electronic cigarettes and traditional cigarettes on brain structures

Brain morphometry in electronic cigarette and traditional cigarette users: an MRI-based analysis

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN26393895

Enrollment

Registered

2026-06-05

Start date

2026-07-01

Completion date

Unknown

Last updated

2026-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neurotoxicity, brain morphometric and structural changes associated with electronic cigarette (vaping) and traditional cigarette use in young adults. Nervous System Diseases

Interventions

Participant Selection and Grouping Participants will be screened and classified into three distinct groups (n=25 per group, total N=75) based on specialized dependency scales and explicit inclusion/ex

Eligibility

Sex/Gender

All

Age

18 Years to 30 Years

Inclusion criteria

Inclusion criteria: 1. Aged between 18 years and 30 years (both sexes included) 2. No known history of central nervous system disease 3. No known chronic systemic diseases (e.g., hypertension, diabetes, metabolic syndrome) 4. No contraindications for MRI scanning (e.g., metallic implants, cardiac pacemakers, neurostimulators, or severe claustrophobia) 5. Capable of giving written informed consent 6. Good MRI image quality without severe motion artifacts 7. Group-specific criteria: 7.1. Minimum 1 year of continuous exclusive use for the EC or TC groups 7.2. Absolute non-use of any nicotine or tobacco products, alcohol, or illicit substances for the healthy control group

Exclusion criteria

Exclusion criteria: 1. History of serious neurological disease (e.g., epilepsy, cerebrovascular events) 2. Severe or unstable psychiatric disorders (e.g., major depressive disorder, schizophrenia, bipolar disorder) 3. Diagnoses affecting brain structure or development, such as ADHD 4. Alcohol or illicit substance use disorder, or active use within the past year 5. Dependence on substances other than nicotine 6. Extremely high or low body mass index (BMI) that could independently influence brain volume 7. Metabolic or chronic inflammatory diseases (e.g., uncontrolled diabetes) 8. Regular use of medications affecting central nervous system activity or structure (e.g., psychotropics, chronic steroids) 9. Pregnancy or lactation 10. Dual users (simultaneous users of both electronic and traditional cigarettes)

Countries

Türkiye

Contacts

Public ContactHüseyin Yigit

huseyin.yigit@kapadokya.edu.tr+905313741235

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Jun 21, 2026