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A cluster randomised trial to assess the impact of opinion leader endorsed evidence summaries on improving quality of prescribing for patients with chronic cardiovascular disease

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN26365328
Enrollment
160
Registered
2005-06-14
Start date
2002-01-01
Completion date
Unknown
Last updated
2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart failure, ischaemic heart disease Circulatory System Chronic ischaemic heart disease

Interventions

The intervention consists of a disease-specific and patient-specific one-page evidence summary. It will be a patient-specific letter addressed to the patients? primary care physician, along with a des

Sponsors

Alberta Heritage Foundation for Medical Research (Canada)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients with HF or IHD who are not currently taking the study medications of interest (Angiotensin-Converting Enzyme [ACE] inhibitors/angiotensin receptor blockers for HF or statins for IHD), and whose primary care physician of record is part of the study. For patients who happen to be eligible for both HF and for IHD, only one condition will be selected at random.

Exclusion criteria

Exclusion criteria: 1. Decline enrolment 2. Unable or unwilling to give informed consent 3. Have previously taken the study medications according to dispensing records 4. Have a documented allergy or intolerance to study medications according to pharmacist records 5. Are in long-term care facilities or institutions 6. Do not confirm on the basis of self-report that they have a diagnosis of either HF or IHD 7. Primary care physician has already contributed 5 patients to the study

Design outcomes

Primary

MeasureTime frame
The primary outcome measure will be the 'improvement' of prescribing for efficacious therapies in patients with a chronic cardiovascular disease within 6 months of the intervention. By study design, none of the study patients will be taking the medications of interest. For HF, starting any ACE inhibitor or angiotensin receptor blocker will be considered a positive outcome. For IHD, starting any statin will be considered a positive outcome. For the primary outcome all positive study-related medication changes will be pooled for an overall estimate of effect, compared with usual care controls.

Secondary

MeasureTime frame
1. Condition-specific 'improvement' in prescribing after 6 months 2. 'Optimization' of dosage for each of the medications prescribed (i.e. ACE inhibitors or angiotensin receptor blockers and statins) 3. Patient adherence (using prescription refill rates based on dispensing records) 4. Potential influence of age and sex on outcomes

Countries

Canada

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026