Evaluation of antibiotic-treated catheters to prevent peritonitis associated with peritoneal dialysis

Clinical evaluation of an antimicrobial-impregnated catheter against peritonitis: the Catheters Against Peritonitis (CAP) study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN26347295

Enrollment

Registered

2024-06-20

Start date

2024-03-31

Completion date

Unknown

Last updated

2026-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adults who opt for peritoneal dialysis and therefore require the insertion of a peritoneal dialysis catheter Urological and Genital Diseases

Interventions

Eligible individuals who have already chosen PD as their preferred renal replacement therapy will be offered the choice to take part in the trial. All participants will have the treated PD catheter i

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18 years or older 2. End-stage kidney disease of any cause 3. Elective PD catheter insertion

Exclusion criteria

Exclusion criteria: 1. Documented allergy to rifampicin, sparfloxaxacin (or any fluoroquinolone), triclosan, or silicone 2. Pregnant, likely to become pregnant, or breastfeeding 3. Emergency PD catheter insertion

Design outcomes

Primary

Measure	Time frame
Safety and tolerability of an antimicrobial-impregnated catheter, measured using the rate of adverse events to the antimicrobials or the impregnation process encountered by PD patients during 6 months of observation	—

Secondary

Measure	Time frame
1. Patient acceptability determined by modified Integrated Palliative Care Outcome Scale (IPOS) Renal questionnaire and patient acceptability questionnaire at baseline, 3 weeks, 3 months and 6 months. 2. Peritoneal dialysis-related infections: PD peritonitis, exit site/tunnel infection identified and defined using local protocols and International Society for Peritoneal Dialysis Guidelines; microorganism antibiotic resistance profile of organisms causing catheter-related infections colonisation of PD catheters removed within the study period, measured using clinical assessment and laboratory culture techniques during 6 months of observation. 3. Technique failure: transfer from peritoneal dialysis to hemodialysis measured using clinical records and observation during 6 months of observation.	—

Measure

Time frame

1. Patient acceptability determined by modified Integrated Palliative Care Outcome Scale (IPOS) Renal questionnaire and patient acceptability questionnaire at baseline, 3 weeks, 3 months and 6 months. 2. Peritoneal dialysis-related infections: PD peritonitis, exit site/tunnel infection identified and defined using local protocols and International Society for Peritoneal Dialysis Guidelines; microorganism antibiotic resistance profile of organisms causing catheter-related infections colonisation of PD catheters removed within the study period, measured using clinical assessment and laboratory culture techniques during 6 months of observation. 3. Technique failure: transfer from peritoneal dialysis to hemodialysis measured using clinical records and observation during 6 months of observation.

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Countries

England, United Kingdom

Contacts

Public ContactMaarten;Roger Taal;Bayston

;

maarten.taal1@nhs.net;roger.bayston@nottingham.ac.ukN/A;N/A

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Jul 23, 2026