Zoonotic causes of acute febrile illness in children Infections and Infestations
Conditions
Interventions
Following consent/assent, a detailed questionnaire on symptoms/signs, socio-economic status, dietary preferences/practices and other household exposures (human, animal, environment) will be completed
Sponsors
University of Liverpool
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Male and female children aged =2 months and 37.5°C, OR a rectal temperature of =38.0°C 3. Caregiver provides full and free informed consent 4. Children aged 8-17 years provide full and free assent
Exclusion criteria
Exclusion criteria: 1. Unknown age 2. Known malignancy, renal failure, hepatic failure, bone marrow aplasia 3. Trauma, surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The presence of one or more bacterial zoonotic pathogens or arboviruses measured using reference standard diagnostics, qPCR and novel diagnostic platforms at presentation to the health centre | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Clinical characteristics measured using clinical history, physical examination and laboratory testing at presentation to the health centre 2. Socio-economic status, dietary preferences/practices and other household exposures measured using questionnaire designed for the study at presentation to the health centre 3. Diagnostic accuracy, time to result, and potential impact on treatment measured using clinical and laboratory records after application of novel diagnostic platforms | — |
Countries
Ethiopia, Kenya, Uganda
Contacts
Public ContactSiobhan Mor
Outcome results
None listed