Atopy in infants and children Signs and Symptoms Atopy
Conditions
Interventions
Active intervention: probiotic supplement consisting of a combination of 4 strains of live bacteria (Lactobacillus salivarius LS33 6.25 x 10^9 cfu [Colony Forming Units], Lactobacillus paracasei CUL08
Sponsors
University of Wales, Swansea (UK)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 600 women and their newborn infants recruited from the antenatal department of a maternity unit of a district general hospital, with informed written consent. Infants have a first degree relative with an atopic disorder.
Exclusion criteria
Exclusion criteria: 1. Mother aged less than 16 years 2. Multiple pregnancy 3. Gestation at delivery less than 36 weeks 4. Parents unable or unwilling to give informed consent 5. Any adverse medical condition affecting the pregnancy or its likely outcome (e.g. known abnormality in foetus) 6. Member of sibship or household already recruited to the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. The presence of eczema during infancy (assessed by the SCORAD system) 2. The presence of asthma in children in the first five years 3. Changes in key immunological parameters associated with atopy | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Compliance with/adherence to trial intervention 2. Adverse events | — |
Countries
United Kingdom, Wales
Outcome results
None listed