Cirrhosis and portal hypertension Digestive System Other diseases of liver
Conditions
Interventions
1. Carvedilol starting at 6.25 mg per day for a week, to increase to 12.5 per day thereafter if tolerated
2. Variceal band ligation to be performed every two weeks until variceal eradication
The foll
Sponsors
University of Edinburgh (UK)
Eligibility
Inclusion criteria
Inclusion criteria: Liver cirrhosis and the presence of Grade II or larger oesophageal varices.
Exclusion criteria
Exclusion criteria: 1. Aged less than 18 or greater than 75 2. Medication: vasoactive drugs such as beta blockers or nitrates 3. Advanced cardiopulmonary disease 4. Malignancy with prognosis that will affect study outcome 5. Allergy to carvedilol 6. Patients with obstructive airways disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The first variceal bleed. The outcomes were measured for the entire follow up period and also at 6, 12, and 24 months. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Overall mortality 2. Variceal bleeding related mortality 3. Adverse events leading to treatment discontinuation The outcomes were measured for the entire follow up period and also at 6, 12, and 24 months. Bleeding induced mortality was defined as death within 6 weeks of the index variceal bleed. | — |
Countries
United Kingdom
Outcome results
None listed