A population-based diabetes cohort: the Hoorn Diabetes Care System cohort

The Hoorn Diabetes Care System cohort (DCS): an observational prospective cohort study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN26257579

Enrollment

16000

Registered

2017-01-06

Start date

1996-10-01

Completion date

Unknown

Last updated

2017-02-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes Nutritional, Metabolic, Endocrine Type 2 diabetes mellitus

Interventions

The DCS cohort study is an observational study and no specific intervention of treatment is performed. All people with type 2 diabetes from all the 103 general practitioners in the West-Friesland re

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: All people (all ages) with type 2 diabetes living in the West-Friesland region of the Netherlands

Exclusion criteria

Exclusion criteria: No exclusions

Design outcomes

Primary

Measure	Time frame
1. Microvascular complications, measured annually: 1.1. Nephropathy: urinary albumin-creatinine ratio (mg/mmol), from an overnight first-voided urine sample 1.2. Kidney function estimated according to the Modification of Diet in Renal Disease (MDRD) formula. Microalbuminuria was defined as urinary albumin-creatinine ratio>2.0 mg/mmol 1.3. Retinopathy, measured by fundus photography of both eyes. All photographs were graded according to the EURODIAB classification score: grade 0: “no retinopathy,” grade 1: “minimal non-proliferative retinopathy,” grade 2: “moderate non-proliferative retinopathy,” grade 3: “severe non-proliferative or pre-proliferative retinopathy,” grade 4: “photocoagulated retinopathy,” and grade 5: “proliferative retinopathy” 1.4. Diabetic foot, determined by dermatologic and musculoskeletal inspection; check for skin pressure and foot deformity; neurological assessment including test of protective sensation using a 10-g monofilament and test of vibratory sensation using a 128-Hz tuning fork; assessing presence of peripheral arterial disease (PAD) by foot pulses; and assessing presence of limited joint mobility. Complications of the foot are categorized according to the classification system of the International Working Group on the Diabetic Foot: 0: no neuropathy, 1: neuropathy, 2: neuropathy and deformity or PAD, 3: history of foot ulceration or a lower-extremity amputation 2. Cardiovascular complications, measured by: 2.1. Self-reported events during the annual visit 2.2. Electrical conduction system, a standard resting 12-lead electrocardiogram coded according to the Minnesota coding, measured annually. 2.3. Electronic patient registration from the regional hospital and GP, updated every three years. In this morbidity and mortality registration, cardiovascular diseases are coded according to the International Classification of Diseases, Injuries and Causes of Death, ninth revision, including ICD-9 codes 390 to 459, and 798 3. Cancer: via li	—

Measure

Time frame

1. Microvascular complications, measured annually: 1.1. Nephropathy: urinary albumin-creatinine ratio (mg/mmol), from an overnight first-voided urine sample 1.2. Kidney function estimated according to the Modification of Diet in Renal Disease (MDRD) formula. Microalbuminuria was defined as urinary albumin-creatinine ratio>2.0 mg/mmol 1.3. Retinopathy, measured by fundus photography of both eyes. All photographs were graded according to the EURODIAB classification score: grade 0: “no retinopathy,” grade 1: “minimal non-proliferative retinopathy,” grade 2: “moderate non-proliferative retinopathy,” grade 3: “severe non-proliferative or pre-proliferative retinopathy,” grade 4: “photocoagulated retinopathy,” and grade 5: “proliferative retinopathy” 1.4. Diabetic foot, determined by dermatologic and musculoskeletal inspection; check for skin pressure and foot deformity; neurological assessment including test of protective sensation using a 10-g monofilament and test of vibratory sensation using a 128-Hz tuning fork; assessing presence of peripheral arterial disease (PAD) by foot pulses; and assessing presence of limited joint mobility. Complications of the foot are categorized according to the classification system of the International Working Group on the Diabetic Foot: 0: no neuropathy, 1: neuropathy, 2: neuropathy and deformity or PAD, 3: history of foot ulceration or a lower-extremity amputation 2. Cardiovascular complications, measured by: 2.1. Self-reported events during the annual visit 2.2. Electrical conduction system, a standard resting 12-lead electrocardiogram coded according to the Minnesota coding, measured annually. 2.3. Electronic patient registration from the regional hospital and GP, updated every three years. In this morbidity and mortality registration, cardiovascular diseases are coded according to the International Classification of Diseases, Injuries and Causes of Death, ninth revision, including ICD-9 codes 390 to 459, and 798 3. Cancer: via li

—

Secondary

Measure	Time frame
Quality of life and physical functioning, assessed by self-reported questionnaires at a single timepoint in 2006	—

Countries

Netherlands

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 26, 2026