End stage renal failure Nutritional, Metabolic, Endocrine
Conditions
Interventions
Usual (standard) peritoneal dialysis solution versus peritoneal dialysis solution with low glucose degradation products
Sponsors
Institute of Kidney Lifescience Technologies (Canada)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age 18 years or above 2. Able to give consent 3. Patient with Peritoneal Dialysis (PD) catheter inserted
Exclusion criteria
Exclusion criteria: 1. Age less than 18 2. Previous hemodialysis 3. Those unlikely to continue peritoneal dialysis for more than six months due to severe comorbid conditions, planned living renal transplantation, or planned transfer to another facility 4. Patients with previous renal transplant 5. Patients starting incremental peritoneal dialysis 6. 24-hour urine volume of less than 100 ml and/or creatinine clearance of less than 1 ml/min 7. Patients with psychiatric diagnoses that might impinge on compliance
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of decline of residual renal function | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Peritoneal ultrafiltration 2. Peritonitis episodes 3. Cardiovascular events (combination of non-fatal myocardial infarction [MI], peripheral vascular disease requiring lower limb amputation, strokes, and deaths due to cardiovascular causes) 4. Peritoneal equilibration test results 5. Peritoneal clearances of urea and creatinine 6. Changes in dialysate CA125 and advanced glycosylated end products | — |
Countries
Canada, China
Outcome results
None listed