Absorption of phytochemicals and effects on endothelial function Nutritional, Metabolic, Endocrine
Conditions
Interventions
One dose of 250 ml of a 20% blackcurrant juice drink in comparison with a control drink lacking flavonoids.
The washout period between the intervention and control dose was 1 month.
Sponsors
GlaxoSmithKline Nutritional Healthcare (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Men and women between the ages of 30-70 years 2. Normal weight 3. Drink no more than 15 units of alcohol (i.e. not more than 7 pints) per week 4. Not regularly undertaking vigorous exercise or fitness training (i.e. not more than 3, 20 minute aerobic sessions per week)
Exclusion criteria
Exclusion criteria: 1. Diabetes 2. Heart disease 3. Gall bladder problems 4. Phenylketonuria (PKU) 5. Known food allergies or intolerances or abnormalities of fat metabolism 6. Trying to lose weight or following other diets 7. Taking dietary supplements 8. Hormone abnormalities or liver disease 9. Regularly use certain types of medication 10. Pregnant, lactating or, if female and of reproductive age, not using a reliable form of contraception (including abstinence)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Endothelial function/vascular reactivity assessed by laser doppler iontophoresis at 0 and 120 minutes. | — |
Secondary
| Measure | Time frame |
|---|---|
| Phytochemical composition (phenolic acids and flavonoids) of plasma and urine was measured at 0.5 hour intervals for the first 4 hours, then 1 hour intervals up to 8 hours. A 24 hour urine sample was also analysed. | — |
Countries
United Kingdom
Outcome results
None listed