Observation of genotype-phenotype interaction effects on white matter in Alzheimer Disease and Bipolar Disorder

Observation of genotype-phenotype interaction effects on white matter in Alzheimer Disease and Bipolar Disorder: a cross-sectional cohort study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN26135594

Enrollment

300

Registered

2012-01-27

Start date

2010-06-01

Completion date

Unknown

Last updated

2019-02-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

1. Alzheimer Disease 2. Bipolar Disorder Nervous System Diseases 1. Alzheimer Disease 2. Bipolar Disorder

Interventions

The study involves three visits per patient. Visit 1: The baseline study visit lasts about two hours and includes: interview of patient, demographic data, diagnoses, medications used,

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: All participants: 1. Aged over 64 years 2. Fluency in Spanish Alzheimer's Disease: Participants must fulfil the NINDS-ADRDA criteria for probable Alzheimer's disease. Bipolar Disorder: Participants must fulfill the DSM-IV’s criteria for bipolar disorder. Health Controls: Participants must not have previous memory complaints.

Exclusion criteria

Exclusion criteria: Significant neurological disease other than AD and BD

Design outcomes

Primary

Measure	Time frame
Correlation between neuregulin 1 (NRG-1) expression and white matter effects in AD and/or BD.	—

Secondary

Measure	Time frame
Machine learning based classification of AD / BD / healthy controls using imaging and genetic data.	—

Countries

Spain

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026