Metformin improves endothelial function, endothelial progenitor cells and cardiovascular risk factors in type 1 diabetes

Metformin improves Endothelial function, endothelial progenitor cells and cardiovascular Risk factors In Type 1 diabetes (MERIT study)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN26092132

Enrollment

Registered

2012-07-13

Start date

2012-05-28

Completion date

Unknown

Last updated

2017-02-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 1 diabetes and cardiovascular disease Nutritional, Metabolic, Endocrine Insulin-dependent diabetes mellitus

Interventions

Patients will be assessed before and after metformin therapy. Prior to commencement of metformin patients will undergo 6 weeks running in period to monitor their glycaemia and exclude presence of hypo

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Type 1 diabetes mellitus 2. Aged 16 years or over 3. HbA1c <= 8.5 4. Duration of diabetes of at least 5 years 5. Stable diabetes control for at least 2 months

Exclusion criteria

Exclusion criteria: 1. Glomerular filtration rate (GFR) < 45 ml/ min/ 1.73m2 2. Woman of childbearing age planning pregnancy 3. Pregnancy and/or lactation 4. Proliferative diabetic retinopathy 5. Cardiovascular disease/ischemic heart disease (IHD) 6. Peripheral vascular disease 7. Cerebrovascular accident (CVA) or transient ischemic attack (TIA) 8. Suspected hypoglycaemia unawareness 9. Impaired cognitive function/ unable to give informed consent 10. History of lactic acidosis 11. Contraindications to metformin 12. History of alcohol problem or drug abuse

Design outcomes

Primary

Measure	Time frame
1. EPCs 2. Hill Colony Assay 3. Endothelial function Measured before and after metformin therapy	—

Secondary

Measure	Time frame
No secondary outcome measures	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 1, 2026