Can dietary changes lead to remission of type 2 diabetes even if a person does not lose weight?

Towards remission of type 2 diabetes without weight loss

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN26058700

Enrollment

Registered

2020-02-26

Start date

2020-01-09

Completion date

Unknown

Last updated

2023-04-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes Nutritional, Metabolic, Endocrine Type 2 diabetes mellitus

Interventions

Participants will follow a low-carbohydrate diet for 5 weeks and be randomized to high>low>high protein or low>high>low protein diets while the carbohydrate intake remains constant. The first two diet

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: This study will recruit 15 people with type 2 diabetes and 15 people without type 2 diabetes Inclusion criteria for all participants: 1. Males and post-menopausal females 2. Aged 45 to 60 years 3. BMI of 23 to 35 kg/m² 4. Reporting a stable weight for 3 months prior to study commencement 5. Must be able to give informed consent, and be willing to follow the diets as described in the telephone screening Specific criteria for group with type 2 diabetes: 1. Must be diagnosed within the last 3 years 2. T2D must be diet-controlled or on metformin only Specific criteria for group without type 2 diabetes: 1. Must have no family history of diabetes

Exclusion criteria

Exclusion criteria: 1. Kidney disease 2. Type 1 diabetes 3. Liver disease 4. Hematologic abnormalities 5. Congestive heart failure 6. Untreated thyroid disease

Design outcomes

Primary

Measure	Time frame
24-hour glucose concentrations measured using the Dexcom G6 during the high protein versus the low protein dietary periods	—

Secondary

Measure	Time frame
1. Fasting glucose concentrations measured using the Dexcom G6 during the high protein versus the low protein dietary periods 2. Post-prandial glucose concentrations for 3 hours following a meal (to be identified from the glucose profiles) measured using the Dexcom G6 during the high protein versus the low protein dietary periods 3. Mean amplitude of glucose excursions measured using the Dexcom G6 during the high protein versus the low protein dietary periods 4. High blood glucose index measured using the Dexcom G6 during the high protein versus the low protein dietary periods 5. Change in bodyweight measured using BlueTooth enabled scales from the first day to the last day of each low protein and high protein period 6. Mean steps per day measured by pedometer during the high protein versus the low protein dietary periods	—

Measure

Time frame

1. Fasting glucose concentrations measured using the Dexcom G6 during the high protein versus the low protein dietary periods 2. Post-prandial glucose concentrations for 3 hours following a meal (to be identified from the glucose profiles) measured using the Dexcom G6 during the high protein versus the low protein dietary periods 3. Mean amplitude of glucose excursions measured using the Dexcom G6 during the high protein versus the low protein dietary periods 4. High blood glucose index measured using the Dexcom G6 during the high protein versus the low protein dietary periods 5. Change in bodyweight measured using BlueTooth enabled scales from the first day to the last day of each low protein and high protein period 6. Mean steps per day measured by pedometer during the high protein versus the low protein dietary periods

—

Countries

England, United Kingdom

Contacts

Public ContactNicola Guess

HighProteinStudy@westminster.ac.uk+44 (0)7951252395

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026