Acute pancreatitis Digestive System
Conditions
Interventions
LIFESPAN is an observational study, therefore there is no intervention performed. Participants who fulfill the inclusion criteria will be asked to spend approximately 2 hours answering a complex quest
Sponsors
University of Pécs Medical School, Momentum Grant of the Hungarian Academy of Sciences
Economic Development and Innovation Operative Programme Grant and Highly Cited Publication Grant of the National Research, Development and Innovation Office
Translational Medicine Foundation
Hungarian Academy of Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients with acute pancreatitis (AP): 1. Aged over 18 years 2. Diagnosed AP on the basis of the “2 out of 3” rules of the IAP/APA guideline: (a) upper abdominal pain; (b) serum amylase or lipase >3x upper limit of normal range; (c) characteristic findings on pancreatic imaging 3. Written informed consent form is signed. Patients with AP in alcohol etiology group: 4. Patients consuming >5 drinks per day or >35 drinks per week for both sexes [= 8.75 units per day; 61.25 units per week] shall be included. Please note that 1 unit of alcohol = 10 ml or 8 g of pure (100%) alcohol. Patients with AP in gallstone etiology group: 5. Presence of gallstone (not sludge). Patients with AP in hypertriglyceridemia etiology group: 6. Triglyceride level in blood over 11 mmol/l. Patients with AP in ‘other’ etiology group: 7. The causative agents do not match either of the first 3 groups, AP is induced by e.g.: endoscopic retrograde cholangiopancreatography (ERCP) (post-ERCP pancreatitis), virus infection, trauma, medicine (drug-induced pancreatitis), congenital anatomical malformation, cystic fibrosis, genetics, gluten sensitive enteropathy etc. Control groups (Patients with no AP history): 8. Aged over 18 years 9. Absence of AP at present as well as in the medical history 10. Written informed consent form is signed Control patients in alcohol group: 11. Patients consuming >5 drinks per day or >35 drinks per week for both sexes [= 8.75 units per day; 61.25 units per week] shall be included. Please note that 1 unit of alcohol = 10 ml or 8g of pure (100%) alcohol. Control patients in gallstone group: 12. Presence of gallstone (not sludge). Control patients in hypertrigliceridaemia group: 13. Triglyceride level over 11 mmol/l. Control patients in hospital-based control group: 14. Hospital admissions in Traumatology, Ophthalmic Department, etc. 15. Control patients in population-based control group
Exclusion criteria
Exclusion criteria: 1. Patients do not have reliable information or data. 2. Patients unlikely to adhere to study requirements.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Personal details and physical and socioeconomic status assessed using questions from the National Health and Nutrition Examination Survey (NHANES 2015-16), the American Community Survey (ACS) and the MacArthur Scale of Subjective Social Status. 2. Medical history assessed using the Acute Pancreatitis Questionnaire (Registry for Pancreatic Patients by Hungarian Pancreatic Study Group). 3. Dietary habits assessed using the Diet History Questionnaire, Version 2.0. 4. Physical activity assessed using the International Physical Activity Questionnaire (IPAQ, long, usual-week version) . 5. Stress levels assessed using the Perceived Stress Scale (10-item version). 6. Sleep quality assessed using the Pittsburgh Sleep Quality Index. All these questionnaires were completed on the day of recruitment. Participants filled in two of each questionnaire - one covering the last year and one covering the last month. 7. Characteristics of acute AP assessed using the Acute Pancreatitis Questionnaire was filled out once by the AP participants only. | — |
Countries
Hungary, Romania
Outcome results
None listed