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Algorithm to predict blood pressure therapy

Association between a pharmacogenomic algorithm to predict blood pressure therapy with blood pressure response to anti-hypertensive therapy: a retrospective pilot study

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ISRCTN
Registry ID
ISRCTN25916392
Enrollment
60
Registered
2025-03-19
Start date
2025-05-01
Completion date
Unknown
Last updated
2025-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension Circulatory System

Interventions

This is a retrospective study of patient records. Clinic blood pressure measured using a non-invasive brachial artery blood pressure device. Patient notes will be reviewed for information regarding nu

Sponsors

University of Auckland
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Participant is able and willing to provide informed consent. 2. Participant is =20 and =50 years of age. 3. Participant with diagnosis of Hypertension for a minimum of 1 year and up to 5 years. 4. Participant has been on the same class/classes of blood pressure medication for a minimum of 6 months. 4.1. Note: A change in dosage, frequency, or specific medication is acceptable as long as there have been no changes to the class/classes of medications prescribed. 5. Participant is currently prescribed and taking one of the following classes of medications alone or in combination with each other: 5.1. Diuretics (thiazide or thiazide-like) 5.2. ACE Inhibitors 5.3. Angiotensin Receptor Blocker (ARB) 5.4. Beta-blockers 5.5. Ca2+ Channel Blockers 6. Evidence that the participant has regular GP visits and is compliant with medication (i.e., collects prescriptions).

Exclusion criteria

Exclusion criteria: 1. Participant has a diagnosis of secondary hypertension or is pregnant. 2. Participant is currently prescribed and taking any additional class of medication(s) for high blood pressure not included in the list above 3. Participant has Systolic blood pressure >190 or Diastolic blood pressure >120 documented within the six months prior to visit. 4. Participant has co-morbidities such as heart failure, myocardial infarction and renal impairment. 5. Any other reason that the participant is inappropriate for study enrolment in the opinion of the Investigator.

Design outcomes

Primary

MeasureTime frame
Clinic blood pressure measured using a non-invasive brachial artery blood pressure device (e.g., oscilometric, auscultation) will be obtained by reviewing patient notes.

Secondary

MeasureTime frame
Obtained by reviewing patient notes: 1. Number and types of medications needed to control blood pressure 2. Time to control 3. Number of clinic visits to control 4. Side effects from hypertension therapy 5. Hypertension associated adverse events during treatment 6. Single nucleotide polymorphisms on 11 genes related to blood pressure will be determined from mouth swab samples

Countries

New Zealand

Contacts

Public ContactJulian Paton
j.paton@auckland.ac.nz+64 9 923 2052

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026