Age-related macular degeneration Eye Diseases Senile macular degeneration (atrophic)(exudative)
Conditions
Interventions
Volunteers will be provided with eggs containing different amounts of the macular pigments, or a normal non-enriched egg, to be taken daily for the duration of the study. They are randomised to 5 grou
Sponsors
The Howard Foundation (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Eligible subjects will have no ocular pathology, no history of cardiovascular disease, no allergy to egg-containing products, low cholesterol and non-smoking status.
Exclusion criteria
Exclusion criteria: Subjects will only be eligible if they have no recent history of supplementation with the macular carotenoids, or cholesterol-lowering statins.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Macular pigment response: measured using the Spectralis OCT (Heidelberg Engineering); cognitive function is measured using CANTAB interactive software (Cambridge Cognition). All measurements will be made for each study visit. Study visits will be completed at baseline and at the end of the trial (week 8). | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum carotenoid response: measured using high performance liquid chromatography (HPLC) | — |
Countries
Ireland
Outcome results
None listed