Prevention of diabetes in South Asians with impaired glucose levels: a family based clinical trial using physical activity and dietary modification

Conditions

Nutritional, Metabolic and Endocrine Diseases: type 2 Diabetes Nutritional, Metabolic, Endocrine Diabetes

Bhopal RS, Douglas A, Wallia S, Forbes JF, Lean ME, Gill JM, McKnight JA, Sattar N, Sheikh A, Wild SH, Tuomilehto J, Sharma A, Bhopal R, Smith JB, Butcher I, Murray GD.

2013-12-23117 citations

10.1016/s2213-8587(13)70204-3

Design and baseline characteristics of the PODOSA (Prevention of Diabetes & Obesity in South Asians) trial: a cluster, randomised lifestyle intervention in Indian and Pakistani adults with impaired glycaemia at high risk of developing type 2 diabetes.

Douglas A, Bhopal RS, Bhopal R, Forbes JF, Gill JM, McKnight J, Murray G, Sattar N, Sharma A, Wallia S, Wild S, Sheikh A.

2013-02-2210 citations

10.1136/bmjopen-2012-002226

Recruiting South Asians to a lifestyle intervention trial: experiences and lessons from PODOSA (Prevention of Diabetes & Obesity in South Asians).

Douglas A, Bhopal RS, Bhopal R, Forbes JF, Gill JM, Lawton J, McKnight J, Murray G, Sattar N, Sharma A, Tuomilehto J, Wallia S, Wild SH, Sheikh A.

2011-10-0662 citations

10.1186/1745-6215-12-220

Interventions

Intervention group will receive 15 contacts with trained dieticians over 3 years with the goal of reducing weight and increasing physical activity. Control group will receive 4 contacts over 3 years t

Eligibility

Inclusion criteria

Inclusion criteria: 1. Self-assigned ethnic group using Census 2001 categories as Indian or Pakistani 2. Normal place of residence is in Greater Glasgow & Clyde or Lothian Health board areas 3. Given informed consent 4. Impaired glucose tolerance (IGT) on oral glucose tolerance test (OGTT) at least once 5. An age of 35 or more 6. A waist size of > 90 cm (men) or > 80 cm (women) 7. No confirmed medical history of diabetes (other than gestational diabetes)

Exclusion criteria

Exclusion criteria: 1. The main cook for the potential participant with IGT is unwilling to give consent to cooperate 2. A diagnosis of diabetes made on the OGTT during the screening phase of the study 3. Other disease where adherence to the intervention is contraindicated or improbable e.g. terminal illness or psychological or physical illnesses; alcohol dependency; planned or actual pregnancy; use of prescribed drugs that affect the primary outcome 4. An expectation, reported by participants or the GP, that the person will be emigrating or dying before the conclusion of the trial 5. Failure to make a commitment to stay in the study until, at least, the three year follow-up examination

Design outcomes

Primary

Measure	Time frame
Current information as of 26/04/10: Weight change at 3 years. Initial information at time of registration: To evaluate whether a 3-year family based programme combining weight loss and physical activity can reduce the incidence of type 2 diabetes in South Asians with impaired glucose tolerance.	—

Secondary

Measure	Time frame
Added 26/04/10: 1. Changes in fasting and 2-hour glucose 2. Progression to type 2 diabetes 3. Body Mass Index (BMI) 4. Waist circumference and hip circumference 5. Cost effectiveness	—

Countries

United Kingdom

Outcome results

None listed