Myocardial Injury following Coronary Artery bypass Surgery versus percutaneous coronary Angioplasty with stents: a randomised controlled trial using biochemical markers and cardiovascular magnetic resonance imaging

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN25699844

Enrollment

Registered

2006-06-06

Start date

2006-06-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multivessel coronary artery disease Circulatory System Coronary artery disease

Interventions

Coronary artery bypass grafting versus percutaneous coronary intervention.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients with greater than or equal to two vessel CAD (greater than or equal to 50% stenosis) including the Left Anterior Descending (LAD), and/or a functionally significant left main stem stenosis of 50% or more 2. Equivalent revascularisation can be provided by PCI and CABG 3. Angina (stable or unstable), or documented silent ischaemia on functional stress testing

Exclusion criteria

Exclusion criteria: 1. Contraindication to aspirin or clopidogrel 2. Women of childbearing potential 3. Non-viable myocardium in the area subtended by diseased vessels 4. Patients requiring concomitant cardiac surgery 5. Acute myocardial infarction

Design outcomes

Primary

Measure	Time frame
The frequency of new myocardial injury following PCI and CABG as assessed by biochemical markers (troponin I) and MRI.	—

Secondary

Measure	Time frame
1. Total amount of new myocardial necrosis (in grams) assessed by MRI 2. Change in left ventricular function assessed by MRI	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 29, 2026