Online therapy programme for fatigue in multiple sclerosis

Effectiveness of a fatigue management programme for patients with Multiple Sclerosis (MS)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN25692173

Enrollment

204

Registered

2014-06-06

Start date

2014-07-01

Completion date

Unknown

Last updated

2018-04-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple Sclerosis (MS) Nervous System Diseases Multiple sclerosis

Interventions

A pure online randomised-wait-list-control study with a subgroup undergoing clinical examination and MRI. Screening of suitable patients will be performed by checking fatigue scores in the Hamburg Qua

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Definite MS according to McDonald criteria (Polman et al., 2010), relapsing-remitting (RR), primary and secondary-progressive (SP) MS course 2. Ability to answer read texts and to answer questionnaires via the internet 3. Fatigue-Scale-Motor-Cognition (FSMC) total fatigue score >= 43 4. Internet equipment at home (PC with internet access) 5. Interest to attend (agreement)

Exclusion criteria

Exclusion criteria: 1. Unclear diagnosis 2. Neuromyelitis optica 3. Major psychiatric disease (f.e. psychotic disease, but we will allow depressive disorders)

Design outcomes

Primary

Measure	Time frame
Fatigue as measured by the Chalder Fatigue Scale (Cella & Chalder et al., 2010). Pre-post training comparisons immediately after the training and 3 months later will be calculated.	—

Secondary

Measure	Time frame
1. Fatigue: FSMC (Penner et al., 2009) 2. Anxiety and depression: Hospital Anxiety and Depression Scale (HADS, Zigmond & Snaith, 1983) 3. Quality of life: Hamburg Quality of Life Questionnaire in MS (HAQUAMS, Gold et al., 2001) 4. Cognitive self assessment: Multiple Sclerosis Neuropsychological Screening Questionnaire (MSNQ, Benedict et al., 2003) Exploratory: 5. Cognitive and behavioural responses to symptoms questionnaire (Skerett & Moss-Morris, 2006) 6. Brief Illness Perception Questionnaire (Broadbent et al., 2006) 7. Coping Self Efficacy Scale (CSES, Chesney et al., 2006) 8. Activity of daily life: Frenchay Activity Index (Turnbull et al., 2000) 9. Personality: Revised NEO Personality Inventory (Costa & McCrae,1992)	—

Measure

Time frame

1. Fatigue: FSMC (Penner et al., 2009) 2. Anxiety and depression: Hospital Anxiety and Depression Scale (HADS, Zigmond & Snaith, 1983) 3. Quality of life: Hamburg Quality of Life Questionnaire in MS (HAQUAMS, Gold et al., 2001) 4. Cognitive self assessment: Multiple Sclerosis Neuropsychological Screening Questionnaire (MSNQ, Benedict et al., 2003) Exploratory: 5. Cognitive and behavioural responses to symptoms questionnaire (Skerett & Moss-Morris, 2006) 6. Brief Illness Perception Questionnaire (Broadbent et al., 2006) 7. Coping Self Efficacy Scale (CSES, Chesney et al., 2006) 8. Activity of daily life: Frenchay Activity Index (Turnbull et al., 2000) 9. Personality: Revised NEO Personality Inventory (Costa & McCrae,1992)

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Countries

Germany

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 24, 2026