COVID-19 (SARS-CoV-2 infection) Infections and Infestations
Conditions
Interventions
The study consists of a single treatment with no follow-up. Participants will be assigned to one of the four arms using a balanced randomisation scheme: Dentyl Mouthwash (Cetylperidium chloride 0.05%
povidone-iodine (PVP-I 0.5% [v/v])
Ultradex (Cetylperidium chloride 0.1% [v/v]) or Normasol (sterile saline 0.9% [v/v]). The three test (active) agents will all be used according to their current marketing approval. Baseline saliva wil
Sponsors
Cardiff University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Eligible patients will be approached and recruited from COVID in-patient wards within Cardiff and Vale University Health Board, Betsi Cadwaladr University Health Board, University Hospitals Bristol NHS Foundation Trust and Cwm Taf Morganwg University Health Board. Only patients who are deemed well enough and able to provide informed consent by their local clinical teams will be approached to take part in the study. Specific inclusion criteria are: 1. Adults aged =18 years 2. With positive SARS-CoV-2 carriage by RT-PCR within 14 days 3. Capable of using the mouthwash required by the trial 4. Capacity and capability to give informed consent to take part in the trial
Exclusion criteria
Exclusion criteria: 1. Known or suspected intolerance or hypersensitivity to povidone-iodine or other study materials (or closely related compounds) or any of their stated ingredients 2. Known pregnancy, currently breastfeeding or women of childbearing age without effective contraception 3. Current requirement for invasive or non-invasive ventilation; or planned within next 6 hours 4. Known dermatitis herpetiformis (Duhring's disease) 5. Inability to communicate in English or read English
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Viral load of SARS CoV-2 measured by in vitro culture and confirmed by RT-qPCR at 30 minutes | — |
Secondary
| Measure | Time frame |
|---|---|
| Viral load of SARS CoV-2 measured by in vitro culture and confirmed by RT-qPCR at baseline and then after 1, 15 and 60 minutes | — |
Countries
England, United Kingdom, Wales
Contacts
Public ContactDavid Thomas
Outcome results
None listed