Prevention of mobility limitation and sarcopenia Musculoskeletal Diseases
Conditions
Interventions
Participants will be randomized to either the resistance training group (intervention) or the flexibility group (control) using an online service known as sealed envelope https://www.sealedenvelope.co
Sponsors
McMaster University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Community-dwelling older adults 70 years of age and older 2. Are preclinically mobility limited based on self-report according to Manty’s preclinical mobility limitation questionnaire 3. Able to walk independently and without assistive devices 4. Are eligible to participate in regular physical activity according to the Canadian Society Exercise Physiology Get Active Questionnaire 5. Have a body mass index (BMI) between 18.5 - 35 kg/m² (inclusive) 6. Willing and able to provide informed consent (speaks and understands English) 7. Generally healthy
Exclusion criteria
Exclusion criteria: 1. Have a history of neuromuscular conditions or muscle-wasting diseases 2. Are currently completing progressive strength training =2x/week (or have within 80% (missing = 8 sessions) of the classes 4. Acute or chronic disease, in the opinion of the Investigator, that interfere with the participants capacity to exercise 5. Diabetes 6. Individuals who have undergone or who are currently undergoing cancer treatment in the last 5 years 7. Current smoker (smoking compromises exercise adaptation) 8. Any concurrent medical, orthopedic, or psychiatric condition that, in the opinion of the Investigator, would compromise his/her ability to comply with the study requirements 9. Excessive alcohol consumption (>21 units/wk) 10. Routine/daily usage of any anabolic or cortico-steroid 11. Do not have access to the internet at home via a personal smartphone, tablet (e.g., iPad), or computer.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Functional capacity measured using various physical function measures such as the short physical performance battery, timed up and go, 6-minute walk test at baseline and the end of each phase. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Strength measured using handgrip and the stair climb power test at baseline and the end of each phase. 2. Proxies of muscle mass measured using Deuterium-labelled creatine (D3-Cr) and dual-energy X-ray absorptiometry (DEXA) at baseline and the end of each phase. 3. Sarcopenia measured using physical function, strength, and muscle mass and the Strength (S), Assistance walking (A), Rising from a chair (R), Climbing stairs (C), and Falls (F) (SARC-F) questionnaire at baseline and end of study. 4. Mobility measured using the Manty preclinical mobility limitation and life-space mobility assessments. at baseline and end of study. 5. Health-related quality of life measured using the SF-36 at baseline and end of study. 6. Physical activity levels measured using accelerometry and the PASE questionnaire. 7. Frailty measured using the Fit-Frailty Index at baseline and end of study. 8. General health measured using bloods and blood pressure at baseline and end of study. | — |
Countries
Canada
Contacts
Public ContactGiulia Coletta
Outcome results
None listed