Genetic and psychometric role in post-surgical acute pain using ASL/regional cerebral blood (rCBF) flow

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN25601281

Enrollment

Registered

2010-10-27

Start date

2007-11-01

Completion date

Unknown

Last updated

2017-07-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Topic: Oral and Gastrointestinal

Interventions

Surgery is undertaken along with MRI scanning and blood tests and psychometric tests.

Eligibility

Inclusion criteria

Inclusion criteria: Not provided at time of registration

Exclusion criteria

Exclusion criteria: Not provided at time of registration

Design outcomes

Primary

Measure	Time frame
Whole brain resting state distribution of Cerebral Blood Flow (rCBF) using continuous labelled ASL with multi-shot fast spin echo (FSE).	—

Secondary

Measure	Time frame
1. Cognitive Coping Strategizing Inventory (CCSI) index 2. Center for Epidemiologic Studies Depression Scale (CES-D) score 3. Computerised Visual Analogue Scale (VAS) measures of perceived intensity of post-surgical pain 4. DNA chip analysis blood 5. DNA chip analysis tissue 6. Eysenck Personality Questionnaire - revised version (EPQ-R) 'E (Extraversion)' and 'N (Neuroticism or Emotionality)' scores 7. Immunohistochemical analysis of known pain receptors 8. Schedule for Clinical Assessment in Neuropsychiatry (SCAN) score 9. The Symptom Checklist-90 - Revised (SCL-90-R) score 10. Students' Test Anxiety Questionnaire (STAQ) pre- and post-trait anxiety and state anxiety score 11. Surgical outcome (difficulty score [1 - 4 scale], depth of impaction, surgery time)	—

Measure

Time frame

1. Cognitive Coping Strategizing Inventory (CCSI) index 2. Center for Epidemiologic Studies Depression Scale (CES-D) score 3. Computerised Visual Analogue Scale (VAS) measures of perceived intensity of post-surgical pain 4. DNA chip analysis blood 5. DNA chip analysis tissue 6. Eysenck Personality Questionnaire - revised version (EPQ-R) 'E (Extraversion)' and 'N (Neuroticism or Emotionality)' scores 7. Immunohistochemical analysis of known pain receptors 8. Schedule for Clinical Assessment in Neuropsychiatry (SCAN) score 9. The Symptom Checklist-90 - Revised (SCL-90-R) score 10. Students' Test Anxiety Questionnaire (STAQ) pre- and post-trait anxiety and state anxiety score 11. Surgical outcome (difficulty score [1 - 4 scale], depth of impaction, surgery time)

—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026