Postherpetic neuraglia (PHN) Nervous System Diseases Cranial nerve disorders in diseases classified elsewhere
Conditions
Interventions
Patients were randomised to receive one of the following treatments, once a week for 3 weeks:
1. Pulsed radiofrequency (42 degree, 120 second) of the intercostal nerve (Thoracic 1 to T12 level)
2. Sh
Sponsors
Xinhua Hospital (China)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age greater than 60 years 2. PHN history is longer than 3 months 3. Pain on Visual Analogue Scale (VAS) >3 (0-10 VAS scale) 4. PHN affected nerve sectors were thoracic nerves from T1 to T12 level 5. Refractory to formal treatment such as antiepileptic medicine, antidepressants, opioids and physical treatments and epidural block
Exclusion criteria
Exclusion criteria: 1. Exclusion criteria included withdraws from the study 2. Poor effect, intolerant to the study 3. Uncooperative and unable to finish the self evaluation (VAS, QOL and SF-36) 4. Coagulation disturbances 5. Allergies to local anaesthetic 6. Malignancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Visual Analogue Scale (VAS) score, measured at baseline, days 3, 7, 14, 30 and 60, 6 months and 1 year 2. Flare pain per day during days 3, 7, 14, 30, 60 and at 6 months 3. Neurometer CPT/C (Neurotron, Inc) to measure three fiber function 4. SF-36 at baseline, 2 months, 6 months and 1 year following-up | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Need to PRF again or other invasive operation at 2 day, 6 month or 1 year following-up 2. Dosage of rescue drug consumed per week at the end of treatment and after 4 weeks follow-up - including Tramadol and/or acetaminophen - and the dosage of combined drug, anti-depressive drug (amitriptyline) 3. Presence, frequency and duration of adverse effects at 7, 14, 30, and 60 days | — |
Countries
China
Outcome results
None listed