Cognitive behavioural treatment of negative symptoms in patients with schizophrenic disorders

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN25455020

Enrollment

198

Registered

2005-11-21

Start date

2006-01-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Schizophrenia Mental and Behavioural Disorders Schizophrenia

Interventions

Cognitive Behavioural Treatment versus Cognitive Remediation

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Schizophrenia (Diagnostic and Statistical Manual of Mental Disorders - fourth edition [DSM-IV] 295.1, 295.2, 295.3, 295.4, 295.6, 295.9) 2. PANSS Modified Negative Syndrome Score =10 3. Fluency of German language

Exclusion criteria

Exclusion criteria: 1. Severe positive symptoms (any item of the standard PANSS positive scale [P1, P2, P3, P4, P5, P6, P7] =6) 2. Severe depression as indicated by PANSS G6 =6 3. Extrapyramidal symptoms 4. Age below 18 or over 55 5. Organic disorder interfering with the central nervous system 6. Verbal IQ <80 7. Diagnosis of substance abuse or substance dependence according to DSM-IV/Structured Clinical Interview for Depression (SCID-I) as primary clinical problem 8. Travel time to the study centre of more than 1 hour

Design outcomes

Primary

Measure	Time frame
PANSS Modified Negative Factor (N1, N2, N3, N4, N6, G7, G16)	—

Secondary

Measure	Time frame
1. Illness related events 2. Scale for the Assessment of Negative Symptoms (SANS) 3. Calgary Depression Scale for Schizophrenia (CDSS) 4. Clinical Global Impression (CGI) 5. Lancashire Quality of Life Profile (LQLP) 6. Social Status 7. Medication Compliance 8. Symptom Checklist 90 Revised (SCL-90-R) 9. Frontal Eye Fields (FEF) 10. Frankfurt Self-concept Scale (FSKN) 11. Neuropsychological assessment	—

Measure

Time frame

1. Illness related events 2. Scale for the Assessment of Negative Symptoms (SANS) 3. Calgary Depression Scale for Schizophrenia (CDSS) 4. Clinical Global Impression (CGI) 5. Lancashire Quality of Life Profile (LQLP) 6. Social Status 7. Medication Compliance 8. Symptom Checklist 90 Revised (SCL-90-R) 9. Frontal Eye Fields (FEF) 10. Frankfurt Self-concept Scale (FSKN) 11. Neuropsychological assessment

—

Countries

Germany

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026