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The use of bowel relaxant Buscopan® to improve the detection of colonic polyps during colonoscopy

The influence of hyoscine N-butylbromide on the colonoscopic polyp detection: A prospective, double blind, randomised, placebo-controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN25405865
Enrollment
672
Registered
2010-11-17
Start date
2010-01-15
Completion date
Unknown
Last updated
2019-04-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colonoscopy

Interventions

Intravenous administration of Buscopan or 0.9% Natriumchloride Solutution (placebo) during colonoscopy. No further interventions The duration of the action of Buscopan

Sponsors

Deventer Hospital (Netherlands)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Patients aged 30 years or older 2. Able to understand and give informed consent 3. Routinely referred for colonoscopy

Exclusion criteria

Exclusion criteria: 1. Pregnancy 2. Myasthenia gravis 3. Exacerbation of inflammatory bowel disease 4. Suspicion of ongoing diverticulitis 5. Expectation of an estimated probability of complete colonoscopy of less than 50%, e.g. by the presence of a stenosis

Design outcomes

Primary

MeasureTime frame
The number of colonoscopies during which at least one polyp has been found divided by the total number of colonoscopies

Secondary

MeasureTime frame
1. Polyp detection score During each colonoscopy the number and shape of the polyps will be recorded. Polyps 10 mm will confer 1 point Scores will be made for flat / broad based polyps as well as rounded / pedunculated polyps. 2. Polyp removal ratio The number of removed polyps divided by the number of detected polyps 3 Pathology retrieval ratio The number of polyps send for pathological investigation divided by the number of removed polyps 4 Influence of age category Categories are: 30 - 50 years, 51 ? 70 years and > 70 years. 5 Influence of diverticulosis category Categories are: 1: 0-2 diverticula, 2: 3-10 diverticula, 3: 11-20 diverticula en 4: > 20 diverticula. 6 Influence of the endocopist

Countries

Netherlands

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 27, 2026